About: A roadmap to engineering antiviral natural products synthesis in microbes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A roadmap to engineering antiviral natural products synthesis in microbes
Creator	Tang, Li Xu, Peng Gu, Yang Ma, Jingbo Zhang, Haoran
Source	Elsevier; Medline; PMC
abstract	Natural products continue to be the inspirations for us to discover and acquire new drugs. The seemingly unstoppable viruses have kept records high to threaten human health and well-being. The diversity and complexity of natural products (NPs) offer remarkable efficacy and specificity to target viral infection steps and serve as excellent source for antiviral agents. The discovery and production of antiviral NPs remain challenging due to low abundance in their native hosts. Reconstruction of NP biosynthetic pathways in microbes is a promising solution to overcome this limitation. In this review, we surveyed 23 most prominent NPs (from more than 200 antiviral NP candidates) with distinct antiviral mode of actions and summarized the recent metabolic engineering effort to produce these compounds in various microbial hosts. We envision that the scalable and low-cost production of novel antiviral NPs, enabled by metabolic engineering, may light the hope to control and eradicate the deadliest viruses that plague our society and humanity.
has issue date	2020-08-12(xsd:dateTime)
bibo:doi	10.1016/j.copbio.2020.07.008
bibo:pmid	32795662
has license	no-cc
sha1sum (hex)	e8d0a4adf7ad6b43a04f2e0e716ec33cb430e6ce
schema:url	https://doi.org/10.1016/j.copbio.2020.07.008
resource representing a document's title	A roadmap to engineering antiviral natural products synthesis in microbes
has PubMed Central identifier	PMC7419324
has PubMed identifier	32795662
schema:publication	Curr Opin Biotechnol
resource representing a document's body	covid:e8d0a4adf7ad6b43a04f2e0e716ec33cb430e6ce#body_text
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