About: The present and future of solution NMR in investigating the structure and dynamics of channels and transporters

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The present and future of solution NMR in investigating the structure and dynamics of channels and transporters
Creator	Oxenoid, Kirill Chou, James
Source	Elsevier; Medline; PMC
abstract	Membrane channels, transporters and receptors constitute essential means for cells to maintain homeostasis and communicate with the surroundings. Investigation of their molecular architecture and the dynamic process of transporting substrate or transmitting signals across the membrane barrier has been one of the frontiers in biomedical research. The past decade has seen numerous successes in the use of x-ray or electron crystallography in determining atomic-resolution structures of membrane proteins, and in some cases, even snapshots of different physiological states of the same protein have been obtained. But there are also many cases in which long-standing efforts to crystallize proteins have yet to succeed. Therefore we have practical needs for developing complementary biophysical tools such as NMR spectroscopy and electron microscopy for tackling these systems. This paper provides a number of key examples where the utility of solution NMR was pivotal in providing structural and functional information of ion channels and transporters.
has issue date	2013-08-01(xsd:dateTime)
bibo:doi	10.1016/j.sbi.2013.03.010
bibo:pmid	23628285
has license	green-oa
sha1sum (hex)	e8530f973d66c8383a8aa7ecca4e514f15445567
schema:url	https://doi.org/10.1016/j.sbi.2013.03.010
resource representing a document's title	The present and future of solution NMR in investigating the structure and dynamics of channels and transporters
has PubMed Central identifier	PMC3740178
has PubMed identifier	23628285
schema:publication	Current Opinion in Structural Biology
resource representing a document's body	covid:e8530f973d66c8383a8aa7ecca4e514f15445567#body_text
is schema:about of	named entity 'utility' named entity 'SOLUTION NMR' named entity 'PRESENT' named entity 'DYNAMICS' named entity 'STRUCTURE' named entity 'SUBSTRATE' named entity 'SUCCESSES' named entity 'COMMUNICATE' named entity 'SIGNALS' named entity 'TRANSMITTING' named entity 'CASES' named entity 'ARCHITECTURE' named entity 'PAST' named entity 'THEIR' named entity 'MOLECULAR' named entity 'PROVIDING' named entity 'STRUCTURAL' named entity 'MEMBRANE CHANNELS' named entity 'TO MAINTAIN' named entity 'NMR SPECTROSCOPY' named entity 'KEY' named entity 'DEVELOPING' named entity 'INFORMATION' named entity 'ONE OF' named entity 'PROTEIN ' named entity 'ACROSS' named entity 'BIOMEDICAL RESEARCH' named entity 'SOLUTION NMR' named entity 'NUMEROUS' named entity 'CELLS' named entity 'TRANSPORTING' named entity 'STRUCTURES' named entity 'HAVE' named entity 'NUMBER OF' named entity 'ATOMIC' named entity 'DIFFERENT' named entity 'MEMBRANE' named entity 'FUNCTIONAL' named entity 'ELECTRON CRYSTALLOGRAPHY' named entity 'PHYSIOLOGICAL STATES' named entity 'PROVIDES' named entity 'SURROUNDINGS' named entity 'X-RAY' named entity 'INVESTIGATION' named entity 'BIOPHYSICAL' named entity 'OBTAINED' named entity 'PROTEINS' named entity 'WHERE' named entity 'CHANNELS' named entity 'FUTURE' named entity 'TRANSPORTERS' named entity 'INVESTIGATING' named entity 'THESE' named entity 'UTILITY' named entity 'MEMBRANE PROTEINS' named entity 'HOMEOSTASIS' named entity 'SYSTEMS' named entity 'DYNAMIC' named entity 'USE OF' named entity 'TRANSPORTERS' named entity 'BARRIER' named entity 'PROCESS' named entity 'SEEN' named entity 'BUT' named entity 'ION CHANNELS' named entity 'ESSENTIAL' named entity 'DECADE' named entity 'TOOLS' named entity 'SNAPSHOTS' named entity 'RESOLUTION' named entity 'RECEPTORS' named entity 'ELECTRON MICROSCOPY' named entity 'NEEDS' named entity 'PAPER' named entity 'MEANS' named entity 'proteins' named entity 'receptors' named entity 'systems' named entity 'paper' named entity 'pivotal'

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