About: A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques

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About: A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques
Creator	Baric, Ralph Johnson, Reed Bartos, Christopher Solomon, Jeffrey Douglas, Madeline Hart, Randy Torzewski, Lisa Cockrell, Adam Bock, Kevin Graham, Rachel Johnson, Joshua Liu, David Moore, Ian
Source	Medline; PMC
abstract	The recurrence of new human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) underscores the need for effective therapeutic countermeasures. Nonhuman primate models are considered the gold standard for preclinical evaluation of therapeutic countermeasures. However, MERS-CoV-induced severe respiratory disease in humans is associated with high viral loads in the lower respiratory tract, which may be difficult to achieve in nonhuman primate models. Considering this limitation, we wanted to ascertain the effectiveness of using a MERS-CoV infectious clone (icMERS-0) previously shown to replicate to higher titers than the wild-type EMC 2012 strain. We observed respiratory disease resulting from exposure to the icMERS-0 strain as measured by CT in rhesus monkeys with concomitant detection of virus antigen by immunohistochemistry. Overall, respiratory disease was mild and transient, resolving by day 30 post-infection. Although pulmonary disease was mild, these results demonstrate for the first time the utility of CT imaging to measure disease elicited by a MERS-CoV infectious clone system in nonhuman primate models.
has issue date	2018-07-16(xsd:dateTime)
bibo:doi	10.1038/s41598-018-28900-1
bibo:pmid	30013082
has license	cc-by
sha1sum (hex)	e835b6338e31398a5abaca8548b69da8e19b61d5
schema:url	https://doi.org/10.1038/s41598-018-28900-1
resource representing a document's title	A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques
has PubMed Central identifier	PMC6048037
has PubMed identifier	30013082
schema:publication	Sci Rep
resource representing a document's body	covid:e835b6338e31398a5abaca8548b69da8e19b61d5#body_text
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