About: Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis

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About: Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
Creator	Al-Farabi, Makhyan Antariksa, Budhi Biomed, M Huang, Ian Pranata, Raymond Santoso, Anwar Wibowo, Arief
Source	Elsevier; Medline; PMC
abstract	Abstract Background In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia. Methods We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19. Results There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34], p < 0.001; I2: 65%). Cardiac injury was associated with higher need for ICU care (RR 7.94 [1.51, 41.78], p = 0.01; I2: 79%), and severe COVID-19 (RR 13.81 [5.52, 34.52], p < 0.001; I2: 0%). The cardiac injury was not significant for increased risk of ARDS (RR 2.57 [0.96, 6.85], p = 0.06; I2: 84%). The level of hs-cTnI was higher in patients with primary + secondary outcome (mean difference 10.38 pg/mL [4.44, 16.32], p = 0.002; I2: 0%). Conclusion Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19.
has issue date	2020-04-19(xsd:dateTime)
bibo:doi	10.1016/j.ajem.2020.04.052
bibo:pmid	32331955
has license	els-covid
sha1sum (hex)	e8358e565d8967826c11dfbb280091de12d4a3bb
schema:url	https://doi.org/10.1016/j.ajem.2020.04.052
resource representing a document's title	Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
has PubMed Central identifier	PMC7166308
has PubMed identifier	32331955
schema:publication	Am J Emerg Med
resource representing a document's body	covid:e8358e565d8967826c11dfbb280091de12d4a3bb#body_text
is schema:about of	named entity 'mortality' named entity 'highly' named entity 'COVID-19' named entity 'Cardiac' named entity 'DATABASES' named entity '0.06' named entity 'NOT SIGNIFICANT' named entity 'CTNI' named entity 'ASSOCIATION' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'CARE' named entity 'COVID-19' named entity 'CONCLUSION' named entity 'ASSOCIATED WITH' named entity 'CARDIAC' named entity 'SEVERE COVID-19' named entity 'secondary' named entity 'mortality' named entity 'severe' named entity 'care' named entity 'COVID-19' named entity 'higher' named entity 'comprehensive' named entity 'COVID-19' named entity 'COVID' named entity 'World Health Organization' named entity 'COVID' named entity 'ARDS' named entity 'pneumonia' named entity 'COVID' named entity 'myocarditis' named entity 'coronavirus 2' named entity 'SARS-CoV-1' named entity 'pericytes' named entity 'Cardiovascular Disease' named entity 'meta-analysis' named entity 'secondary immune response' named entity 'capillary' named entity 'virus' named entity 'Wuhan' named entity 'clinical presentation' named entity 'Acute Respiratory Distress Syndrome' named entity 'hypertension' named entity 'ICU' named entity 'fat' named entity 'Older patients' named entity 'receptor' named entity 'prognostication' named entity 'pericytes' named entity 'SARS-CoV-2' named entity 'critically ill' named entity 'SARI' named entity 'surrogate marker' named entity 'epidemiological' named entity 'pandemics' named entity 'SARS-CoV-1' named entity 'COVID-19' named entity 'Case reports' named entity 'troponin' named entity 'risk of death' named entity 'global outbreak' named entity 'hypotension' named entity 'ARDS' named entity 'pneumonia' named entity 'clinical presentation' named entity 'endothelial dysfunction' named entity 'duplicate publication' named entity 'mortality rate' named entity 'COVID' named entity 'COVID' named entity 'COVID' named entity 'acute respiratory distress syndrome' named entity 'COVID' named entity 'cTnI' named entity 'cytokine storm syndrome'

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