About: Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy
Creator	Martinón-Torres, Federico Salas, Antonio Rivero-Calle, Irene Gómez-Rial, Jose
Source	Medline; PMC
abstract	Emerging studies from SARS-CoV-2-infected patients indicate a preponderant role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to that previously observed in other coronavirus outbreaks (SARS and MERS). The clinical presentation of severe patients resembles viral-associated hemophagocytic syndrome, a rare condition previously seen during lethal influenza pandemics and during previous SARS and MERS coronavirus outbreaks. SARS-CoV-2 infection triggers an over-exuberant inflammatory response due to the development of a cytokine storm and the depletion of the adaptative immune compartment, which may prelude sepsis in many cases. The present review summarizes past evidence on the role of monocytes/macrophages in previous coronavirus outbreaks and the emerging knowledge on their role in COVID-19 pathogenesis. Treatment strategies incorporating the blockade of migration and differentiation of monocyte-macrophage, such as granulocyte macrophage-colony stimulating factor inhibitors, might enhance the promising results seen so far with selective cytokine blockade.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.2147/idr.s258639
bibo:pmid	32801787
has license	cc-by-nc
sha1sum (hex)	e79e68ebbbd5d1dd8bea17c85910a89385030346
schema:url	https://doi.org/10.2147/idr.s258639
resource representing a document's title	Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy
has PubMed Central identifier	PMC7383015
has PubMed identifier	32801787
schema:publication	Infect Drug Resist
resource representing a document's body	covid:e79e68ebbbd5d1dd8bea17c85910a89385030346#body_text
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