About: Application of siRNA Against SARS in the Rhesus Macaque Model

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Application of siRNA Against SARS in the Rhesus Macaque Model
Creator	Lu, Patrick Woodle, Martin Tang, Qingquan Li, Baojian
topic	covid:e78f5fd17168e653f6399e064ed969e52ed612ff#this
Source	Medline; PMC
abstract	Containment of the SARS coronavirus (SCV) outbreak was accompanied by the rapid characterization of this new pathogen's genome sequence in 2003, encouraging the development of anti-SCV therapeutics using short interfering RNA (siRNA) inhibitors. A pair of siRNA duplexes identified as potent SCV inhibitors in vitro was evaluated for in vivo efficacy and safety in a rhesus macaque SARS model using intranasal administration with clinical viable delivery carrier in three dosing regimens. Observations of SCV-induced SARS-like symptoms, measurements of SCV RNA presence in the respiratory tract, microscopic inspections of lung histopathology, and immunohistochemistry sections from 21 tested macaques consistently demonstrated siRNA-mediated anti-SCV activity. The prophylactic and therapeutic efficacies resulted in relief of animals from SCV infection-induced fever, diminished SCV in upper airway and lung alveoli, and milder acute diffuse alveoli damage (DAD). The dosages of siRNA used, 10 to 40 mg/kg, did not show any sign of siRNA-induced toxicity. These results support that a clinical investigation of this anti-SARS siRNA therapeutic agent is warranted. The study also illustrates the capability of siRNA to enable a massive reduction in development time for novel targeted therapeutic agents. We detail a representative example of large-mammal siRNA use.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.1007/978-1-59745-191-8_11
bibo:pmid	18369784
has license	no-cc
sha1sum (hex)	e78f5fd17168e653f6399e064ed969e52ed612ff
schema:url	https://doi.org/10.1007/978-1-59745-191-8_11
resource representing a document's title	Application of siRNA Against SARS in the Rhesus Macaque Model
has PubMed Central identifier	PMC7121115
has PubMed identifier	18369784
schema:publication	RNAi
resource representing a document's body	covid:e78f5fd17168e653f6399e064ed969e52ed612ff#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e78f5fd17168e653f6399e064ed969e52ed612ff
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