About: Increase in cardiovascular pathology in female sprague-dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl

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About: Increase in cardiovascular pathology in female sprague-dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increase in cardiovascular pathology in female sprague-dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl
Creator	Haseman, Joseph Nyska, Abraham Brix, Amy Jokinen, Micheal Sells, Donald Walker, Nigel
topic	covid:e7809b2788f226562b5039dc117540f052b0a4b5#this
Source	Medline; PMC
abstract	The effects of chronic exposure to dioxin (2,3,7,8,-tetrachlorodibenzo-p-dioxin [TCDD]) and a dioxin-like compound (3,3′,4,4′,5-pentachlorobiphenyl [PCB126]) on the cardiovascular system were evaluated in female Harlan Sprague-Dawley rats as part of an ongoing National Toxicology Program investigation. The animals were gavage treated 5 d per week with up to 1000 ng of PCB126 per kilogram of body weight per day or up to 100 ng of TCDD per kilogram of body weight per day for up to 2 yr. The control animals received only a corn oil/acetone vehicle (99:1 mixture). The corresponding stop-study groups received the highest doses for 31 wk and then received only the vehicle for the remainder of the study. After a full necropsy of all animals, a complete set of tissues was examined microscopically. Administration of each compound was associated with treatment-related increases in the incidences of degenerative cardiovascular lesions. Cardiomyopathy and chronic active arteritis increased in a dose-related manner in all groups treated with PCB126 or with TCDD. Increased incidences were also observed in the stop-study groups, indicating that a shorter term exposure may produce some effects. The average severity of cardiomyopathy was minimal or slightly greater in all dose groups, including the controls. Chronic active arteritis occurred primarily in the mesentery and pancreas, although the rectum, liver, heart, ovary, uterus, and glandular stomach in the PCB126 study and the liver and ovary in the TCDD study were affected in a few of the dosed animals. The authors’ investigations indicate that the rat cardiovascular system is a target for dioxin toxicity, which increases the incidence of spontaneous cardiomyopathy and arteritis.
has issue date	2003-01-01(xsd:dateTime)
bibo:doi	10.1385/ct:3:4:299
bibo:pmid	14734827
has license	no-cc
sha1sum (hex)	e7809b2788f226562b5039dc117540f052b0a4b5
schema:url	https://doi.org/10.1385/ct:3:4:299
resource representing a document's title	Increase in cardiovascular pathology in female sprague-dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl
has PubMed Central identifier	PMC7090859
has PubMed identifier	14734827
schema:publication	Cardiovasc Toxicol
resource representing a document's body	covid:e7809b2788f226562b5039dc117540f052b0a4b5#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/e7809b2788f226562b5039dc117540f052b0a4b5
is schema:about of	named entity 'compound' named entity 'liver' named entity 'cardiomyopathy' named entity 'chronic' named entity 'stomach' named entity 'Pathology' named entity 'CHRONIC ACTIVE' named entity 'ADMINISTRATION' named entity 'IS A' named entity 'INCREASED' named entity 'GAVAGE' named entity 'HEART' named entity 'BODY WEIGHT' named entity 'LESIONS' named entity '2C5' named entity 'FOLLOWING' named entity 'INDUCED' named entity 'CARDIOVASCULAR DISEASE' named entity 'TREATMENT' named entity 'animals' named entity 'shorter' named entity 'evaluated' named entity 'incidences' named entity 'received' named entity 'produce' named entity 'microscopically' named entity 'kilogram' named entity 'Sprague-Dawley' named entity 'Rats' named entity 'necropsy' named entity 'ovary' named entity 'Cardiomyopathy' named entity 'body weight' named entity 'examined microscopically' named entity 'pancreas' named entity 'kilogram' named entity 'Rat' named entity 'Cardiovascular' named entity 'ground substance' named entity 'TCDD' named entity 'necrotic' named entity 'arteritis' named entity 'pathology' named entity 'shear stress' named entity 'polyarteritis nodosa' named entity 'carcinogenicity' named entity 'AHR' named entity 'cardiomyopathy' named entity 'dioxin-like compounds' named entity 'deficient mice' named entity 'Thrombosis' named entity 'arterial wall' named entity 'necrosis' named entity 'nodules' named entity 'fibrosis' named entity 'cardiac arrhythmia' named entity 'interventricular septum' named entity 'vascular lesions' named entity 'molecular data' named entity 'cardiomyopathy' named entity 'theophylline' named entity 'inflammatory cell' named entity 'cardiomyopathy' named entity 'cardiomyopathy' named entity 'etiology' named entity 'gavage' named entity 'vasodilator' named entity 'tunica media' named entity 'Arteritis' named entity 'mice' named entity 'Bailer' named entity 'AHR' named entity 'polyarteritis' named entity 'vasoactive'

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