About: Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions

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About: Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions
Creator	Hardestam, Jonas Klingström, Jonas Mirazimi, Ali Falk, Kerstin Lundkvist, Ke Rottenberg, Martin Simon, Melinda Stoltz, Malin
Source	Medline; PMC
abstract	Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to RNI. In this study, we compared the effects of NO and peroxynitrite on hantavirus replication and free mature virions in vitro, and of inducible nitric oxide synthase (iNOS) in hantavirus‐infected suckling mice. The NO‐generating compound S‐nitroso‐N‐acetylpenicillamine (SNAP), as well as cytokine‐induced NO, strongly inhibited hantavirus replication in Vero E6 cells, while pretreatment of free virions with SNAP only had a limited effect on their viability. In contrast, 3‐morpholinosydnonimine hydrochloride (SIN‐1), a peroxynitrite donor, inhibited virus replication only to a very low extent in vitro, but pretreatment of virus with SIN‐1 led to a considerably lowered viability of the virions. Infections of various human cell types per se did not induce NO production. The viral titers in iNOS(–/–) mice were higher compared to the controls, suggesting that NO inhibits hantavirus replication in vivo. In conclusion, we show that NO has strong antiviral effects on hantavirus replication, and peryoxynitrite on mature free virions, suggesting that different RNI can have different effects on various parts of the replication cycle for the same virus.
has issue date	2006-09-06(xsd:dateTime)
bibo:doi	10.1002/eji.200535587
bibo:pmid	16955520
has license	no-cc
sha1sum (hex)	e72c4e9345591eede1aa185827f561f660823264
schema:url	https://doi.org/10.1002/eji.200535587
resource representing a document's title	Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions
has PubMed Central identifier	PMC7163486
has PubMed identifier	16955520
schema:publication	Eur J Immunol
resource representing a document's body	covid:e72c4e9345591eede1aa185827f561f660823264#body_text
is schema:about of	named entity 'mice' named entity 'virus' named entity 'hydrochloride' named entity 'induce' named entity 'replication' named entity 'hantavirus' named entity 'SIN' named entity 'VIRUS REPLICATION' covid:arg/e72c4e9345591eede1aa185827f561f660823264 named entity 'replication' named entity 'limited' named entity 'SIN' named entity 'virions' named entity 'virions' named entity 'RNI' named entity 'replication cycle' named entity 'L-NMMA' named entity 'enzyme' named entity 'titration' named entity 'Vero E6' named entity 'FFU' named entity 'iNOS' named entity 'hantavirus' named entity 'HTNV' named entity 'St. Louis' named entity 'HFRS' named entity 'Nitric oxide' named entity 'Nitric oxide' named entity 'lysis buffer' named entity 'Nitric oxide' named entity 'pathogenesis' named entity 'nucleocapsid' named entity 'RNA' named entity 'nitric oxide' named entity 'peroxynitrite' named entity 'compound' named entity 'compared' named entity 'viral' named entity 'hantavirus' named entity 'effects' named entity 'virus' named entity 'nitric oxide' named entity 'antiviral' named entity 'virus' named entity 'nitric oxide' named entity 'nitric oxide' named entity 'nitric oxide' named entity 'virions' named entity 'virions' named entity 'virions' named entity 'hantavirus' named entity 'iNOS' named entity 'Bunyaviridae' named entity 'antiviral' named entity 'S-nitroso-N-acetylpenicillamine' named entity 'replication cycle' named entity 'mice' named entity 'Nitric oxide' named entity 'infection' named entity 'infection' named entity 'peroxynitrite' named entity 'pathogenesis' named entity 'peroxynitrite' named entity 'Nitric oxide' named entity 'peroxynitrite' named entity 'iNOS' named entity 'Nitric oxide' named entity 'peroxynitrite' named entity 'NOS' named entity 'NOS' named entity 'supernatant' named entity 'Nitric oxide' named entity 'Hantaviruses' named entity 'DOBV'

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