About: Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments

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About: Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments
Creator	Zeng, Fanya Chan, Kwok Chi, Frederick Chow, Ching Hon, Chung Leung, Ching Peiris, Joseph Yan, Ken Yip, Chi Law, Ka
source	Elsevier; Medline; PMC
abstract	Abstract The immunological characteristics of SARS-CoV spike protein were investigated by administering mice with plasmids encoding various S gene fragments. We showed that the secreting forms of S1, S2 subunits and the N-terminus of S1 subunit (residues 18–495) were capable of eliciting SARS-CoV specific antibodies and the region immediate to N-terminus of matured S1 protein contained an important immunogenic determinant for elicitation of SARS-CoV specific antibodies. In addition, mice immunized with plasmids encoding S1 fragment developed a Th1-mediated antibody isotype switching. Another interesting finding was that mouse antibodies elicited separately by plasmids encoding S1 and S2 subunits cooperatively neutralized SARS-CoV but neither the S1 nor S2 specific antibodies did, suggesting the possible role of both S1 and S2 subunits in host cell docking and entry. These results provide insights into understanding the immunological characteristics of spike protein and the development of subunit vaccines against SARS-CoV.
has issue date	2004-03-19(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2004.01.166
bibo:pmid	14985131
has license	els-covid
sha1sum (hex)	e711cafe8a0e573a41064b78e9cbf54a375ac886
schema:url	https://doi.org/10.1016/j.bbrc.2004.01.166
resource representing a document's title	Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments
has PubMed Central identifier	PMC7111006
has PubMed identifier	14985131
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:e711cafe8a0e573a41064b78e9cbf54a375ac886#body_text
is schema:about of	named entity 'SARS-COV' named entity 'gene' named entity 'SARS-CoV' named entity 'host' named entity 'separately' named entity 'plasmid' named entity 'IMMUNIZED' named entity 'GENE' named entity 'PROTEIN ' named entity 'ADDITION' named entity 'DID' named entity 'SECRETING' named entity 'BUT' named entity 'INVESTIGATED' named entity 'IMMUNIZED' named entity 'SUBUNIT VACCINES' named entity 'ISOTYPE SWITCHING' named entity 'VARIOUS' named entity 'IMMEDIATE' named entity 'DETERMINANT' named entity 'IMMUNOLOGICAL' named entity 'FRAGMENTS' named entity 'THESE' named entity 'MEDIATED' named entity 'ADMINISTERING' named entity 'TH1' named entity 'PROVIDE' named entity 'ELICITED' named entity 'MOUSE' named entity 'SARS-COV' named entity 'SPIKE PROTEIN' named entity 'IMPORTANT' named entity 'INTERESTING' named entity 'HOST CELL' named entity 'ENTRY' named entity 'FINDING' named entity 'SUBUNIT' named entity 'REGION' named entity 'UNDERSTANDING' named entity 'IMMUNOGENIC' named entity 'CONTAINED' named entity 'ROLE' named entity 'CAPABLE' named entity 'DEVELOPMENT' named entity 'DOCKING' named entity 'CHARACTERIZATION' named entity 'SPIKE' named entity 'DNAS' named entity 'ENCODING' named entity 'RESPONSES' named entity 'FRAGMENTS' named entity 'MICE' named entity 'N-TERMINUS' named entity 'INSIGHTS' named entity 'SPECIFIC' named entity 'NEITHER' named entity 'ENCODING' named entity 'FORMS' named entity 'ANTIBODIES' named entity 'POSSIBLE' named entity 'RESULTS' named entity 'PLASMIDS' named entity 'MICE' named entity 'ELICITING' named entity 'PLASMID' named entity 'CHARACTERISTICS' named entity 'ANTIBODY ISOTYPE' named entity 'GENE' named entity 'FRAGMENT' covid:arg/e711cafe8a0e573a41064b78e9cbf54a375ac886 named entity 'isotype switching' named entity 'contained'

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