About: Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity
Creator	Sood, Vikas Lin, Chiou-Feng Bordignon, Juliano Jhan, Ming-Kai Shen, Ting-Jing Tsai, Tsung-Ting Tseng, Po-Chun Chen, Chia-Ling Fiocruz, Hsieh, Tzu-Han Brazil, Thawornchai Foundation, Oswaldo Limjindaporn,
Source	Medline; PMC
abstract	Aging and chronic condition increase the incidence of dengue virus (DENV) infection, generally through a mechanism involving immunosenescence; however, the alternative effects of cellular senescence, which alters cell susceptibility to viral infection, remain unknown. Human monocytic THP-1 cells (ATCC TIB-202) treated with D-galactose to induce cellular senescence were susceptible to DENV infection. These senescent cells showed increased viral entry/binding, gene/protein expression, and dsRNA replication. The use of a replicon system showed that pharmacologically induced senescence did not enhance the effects on viral protein translation. By examining viral receptor expression, we found increased expression of CD209 (DC-SIGN) in the senescent cells. Interleukin (IL)-10 was aberrantly produced at high levels by the senescent cells, and the expression of the DENV receptor DC-SIGN was increased in these senescent cells, partially via IL-10-mediated regulation of the JAK2-STAT3 signaling pathway. The results demonstrate that a senescent phenotype facilitates DENV infection, probably by increasing DC-SIGN expression.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.3389/fcimb.2020.00375
bibo:pmid	32850477
has license	cc-by
sha1sum (hex)	e6c9f2e18d422c3337a283c8dea6b10786b99e58
schema:url	https://doi.org/10.3389/fcimb.2020.00375
resource representing a document's title	Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity
has PubMed Central identifier	PMC7399640
has PubMed identifier	32850477
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:e6c9f2e18d422c3337a283c8dea6b10786b99e58#body_text
is schema:about of	named entity 'pharmacologically' named entity 'DC-SIGN' named entity 'The' named entity 'Human' named entity 'high' named entity 'THP-1 CELLS' covid:arg/e6c9f2e18d422c3337a283c8dea6b10786b99e58 named entity 'induce' named entity 'monocytic' named entity 'gene' named entity 'effects' named entity 'generally' named entity 'The' named entity 'alternative' named entity 'partially' named entity 'expression' named entity 'TIB' named entity 'senescence' named entity 'Interleukin' named entity 'CD209' named entity 'Infection' named entity 'D-galactose' named entity 'senescence' named entity 'chronic condition' named entity 'IL-10' named entity 'protein expression' named entity 'CD209' named entity 'DC-SIGN' named entity 'monocytic' named entity 'cellular senescence' named entity 'DENV' named entity 'Infectivity' named entity 'viruses' named entity 'Szirák' named entity 'cytomegalovirus' named entity 'older adults' named entity 'Abcam' named entity 'viral replication' named entity 'infection' named entity 'dengue' named entity 'Exogenous' named entity 'dengue' named entity 'monocytes' named entity 'fluorescein isothiocyanate' named entity 'plaque forming units' named entity 'senescence' named entity 'older adults' named entity 'D-galactose' named entity 'South America' named entity '250 mM' named entity 'D-galactose' named entity 'virulence' named entity 'cellular senescence' named entity 'dengue' named entity 'IgG' named entity 'D-galactose' named entity 'cell senescence' named entity 'macrophages' named entity 'Rockville, MD' named entity 'monocytes' named entity 'replicon' named entity 'senescent' named entity 'chronic disorders' named entity 'IL-10' named entity 'chronic diseases' named entity 'STAT3' named entity 'Aedes albopictus' named entity 'antibodies' named entity 'signaling pathway'

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