About: Using Pan RNA-Seq Analysis to Reveal the Ubiquitous Existence of 5′ and 3′ End Small RNAs

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About: Using Pan RNA-Seq Analysis to Reveal the Ubiquitous Existence of 5′ and 3′ End Small RNAs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Using Pan RNA-Seq Analysis to Reveal the Ubiquitous Existence of 5′ and 3′ End Small RNAs
Creator	Ruan, Jishou Zhang, Tao Huang, Tao Chen, Ze Zhao, Qiang Yao, Xue Bu, Wenjun Gao, Shan Ji, Haishuo Cheng, Zhi Jin, Xiufeng Liu, Yanqiang Xu, Xiaofeng Liu, Yao Canada, Agri-Food Cn, Chenze@caas Fu, Fuyou Zhang, Tuo
topic	covid:e6a3a6591a7468ae5fdb3efcf43fa0dce1b0b00c#this
Source	Medline; PMC
abstract	In this study, we used pan RNA-seq analysis to reveal the ubiquitous existence of both 5′ and 3′ end small RNAs (5′ and 3′ sRNAs). 5′ and 3′ sRNAs alone can be used to annotate nuclear non-coding and mitochondrial genes at 1-bp resolution and identify new steady RNAs, which are usually transcribed from functional genes. Then, we provided a simple and cost effective way for the annotation of nuclear non-coding and mitochondrial genes and the identification of new steady RNAs, particularly long non-coding RNAs (lncRNAs). Using 5′ and 3′ sRNAs, the annotation of human mitochondrial was corrected and a novel ncRNA named non-coding mitochondrial RNA 1 (ncMT1) was reported for the first time in this study. We also found that most of human tRNA genes have downstream lncRNA genes as lncTRS-TGA1-1 and corrected the misunderstanding of them in previous studies. Using 5′, 3′, and intronic sRNAs, we reported for the first time that enzymatic double-stranded RNA (dsRNA) cleavage and RNA interference (RNAi) might be involved in the RNA degradation and gene expression regulation of U1 snRNA in human. We provided a different perspective on the regulation of gene expression in U1 snRNA. We also provided a novel view on cancer and virus-induced diseases, leading to find diagnostics or therapy targets from the ribonuclease III (RNase III) family and its related pathways. Our findings pave the way toward a rediscovery of dsRNA cleavage and RNAi, challenging classical theories.
has issue date	2019-02-14(xsd:dateTime)
bibo:doi	10.3389/fgene.2019.00105
bibo:pmid	30838030
has license	cc-by
sha1sum (hex)	e6a3a6591a7468ae5fdb3efcf43fa0dce1b0b00c
schema:url	https://doi.org/10.3389/fgene.2019.00105
resource representing a document's title	Using Pan RNA-Seq Analysis to Reveal the Ubiquitous Existence of 5′ and 3′ End Small RNAs
has PubMed Central identifier	PMC6382676
has PubMed identifier	30838030
schema:publication	Front Genet
resource representing a document's body	covid:e6a3a6591a7468ae5fdb3efcf43fa0dce1b0b00c#body_text
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