About: Influenza Infections and Emergent Viral Infections in Intensive Care Unit

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza Infections and Emergent Viral Infections in Intensive Care Unit
Creator	Martin-Loeches, Ignacio Luyt, Charles-Edouard Cantan, Ben
Source	Medline; PMC
abstract	Critically ill patients are admitted to an intensive care unit (ICU) for multiple reasons. In this study, we aim to analyze the current evidence and findings associated with influenza and other emergent viral infections, namely, herpes simplex virus type 1 (HSV-1), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Among medical conditions, community-acquired respiratory infections are the most frequent reason for ventilatory support in ICUs. Community-acquired pneumonia in a severe form including the need of invasive mechanical ventilation and/or vasopressors is associated with high mortality rates. However, after the pandemic that occurred in 2009 by H1N1 influenza, the number of cases being admitted to ICUs with viral infections is on the rise. Patients in whom an etiology would not have been identified in the past are currently being tested with more sensitive viral molecular diagnostic tools, and patients being admitted to ICUs have more preexisting medical conditions that can predispose to viral infections. Viral infections can trigger the dysregulation of the immune system by inducing a massive cytokine response. This cytokine storm can cause endothelial damage and dysfunction, deregulation of coagulation, and, consequently, alteration of microvascular permeability, tissue edema, and shock. In severe influenza, this vascular hyperpermeability can lead to acute lung injury, multiorgan failure, and encephalopathy. In immunocompetent patients, the most common viral infections are respiratory, and influenza should be considered in patients with severe respiratory failure being admitted to ICU. Seasonality and coinfection are two important features when considering influenza as a pathogen in critically ill patients. Herpesviridae (HSV, CMV, and EBV) may reactivate in ICU patients, and their reactivation is associated with morbidity/mortality. However, whether a specific treatment may impact on outcome remains to be determined.
has issue date	2019-10-04(xsd:dateTime)
bibo:doi	10.1055/s-0039-1693497
bibo:pmid	31585475
has license	no-cc
sha1sum (hex)	e67b6e20ffe387ec2d2ad69b818748c6cec2689a
schema:url	https://doi.org/10.1055/s-0039-1693497
resource representing a document's title	Influenza Infections and Emergent Viral Infections in Intensive Care Unit
has PubMed Central identifier	PMC7117087
has PubMed identifier	31585475
schema:publication	Semin Respir Crit Care Med
resource representing a document's body	covid:e67b6e20ffe387ec2d2ad69b818748c6cec2689a#body_text
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