About: Regulation of human insulin gene expression in transgenic mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of human insulin gene expression in transgenic mice
Creator	Wu, E Amzel, F Bilofsky, T Bioi ; Kabat, W Bruccoleri, J Chern ; Briiggemann, R Chothia, H Fersht, K Huber, J Karplus, R Marquart, J Novotny, C Oeisenhofer, M Palm, R Perry, M Poljak, M Radbruch, M Rajewsky, A Reid-Miller, H Saul, M
Source	PMC
abstract	Insulin is a polypeptide hormone of major physiological importance in the regulation of fuel homeostasis in animals (reviewed in refs 1, 2). It is synthesized by the (β)-cells of pancreatic islets, and circulating insulin levels are regulated by several small molecules, notably glucose, amino acids, fatty acids and certain pharmacological agents. Insulin consists of two polypeptide chains (A and B, linked by disulphide bonds) that are derived from the proteolytic cleavage of proinsulin, generating equimolar amounts of the mature insulin and a connecting peptide (C-peptide). Humans, like most vertebrates, contain one proinsulin gene(3,4), although several species, including mice(5) and rats(6,7), have two highly homologous insulin genes. We have studied the regulation of serum insulin levels and of insulin gene expression by generating a series of transgenic mice containing the human insulin gene. We report here that the human insulin gene is expressed in a tissue-specific manner in the islets of these transgenic mice, and that serum human insulin levels are properly regulated by glucose, amino acids and tolbutamide, an oral hypoglycaemic agent.
has issue date	1986-01-01(xsd:dateTime)
bibo:doi	10.1038/321525a0
bibo:pmid	3520336
has license	no-cc
sha1sum (hex)	e63fe5d6d56707236dff384626b7d1ad7a14d9b7
schema:url	https://doi.org/10.1038/321525a0
resource representing a document's title	Regulation of human insulin gene expression in transgenic mice
has PubMed Central identifier	PMC7095452
has PubMed identifier	3520336
schema:publication	Nature
resource representing a document's body	covid:e63fe5d6d56707236dff384626b7d1ad7a14d9b7#body_text
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