About: Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats

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About: Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats
Creator	Jia, Hongwei Troccoli, Fernando Dias, Carlos Switzer, William Augusto, Anderson Cavalcante, Liliane Medeiros, Sheila Muniz, Cláudia Santos, André Soares, Marcelo
topic	covid:e620067ec156a1fc9e5b28aaf66b38dd08815df8#this
Source	Medline; PMC
abstract	Feline foamy virus (FFV) and feline leukemia virus (FeLV) belong to the Retroviridae family. While disease has not been reported for FFV infection, FeLV infection can cause anemia and immunosuppression (progressive infection). Co-infection with FFV/FeLV allows evaluation of the pathogenic potential and epidemiology of FFV infection in cats with FeLV pathology. Blood and buccal swab samples from 81 cats were collected in Rio de Janeiro. Plasma was serologically tested for FeLV. DNA extracted from peripheral blood mononuclear cells and buccal swabs was used to PCR detect FFV and FeLV. A qPCR was developed to detect and measure FFV proviral loads (pVLs) in cats. FeLV qPCR was performed using previous methods. The median log10 pVL of FFV mono-infected individuals was lower than found in FFV/FeLV co-infected cats in buccal swabs (p = 0.003). We found 78% of cats had detectable buccal FFV DNA in FFV mono-infected and FFV co-infected FeLV-progressive cats, while in FeLV-regressive cats (those without signs of disease) 22% of cats had detectable buccal FFV DNA (p = 0.004). Our results suggest that regressive FeLV infection may reduce FFV saliva transmission, the main mode of FV transmission. We did not find evidence of differences in pathogenicity in FFV mono- and -dually infected cats. In summary, we show that FVs may interact with FeLV within the same host. Our study supports the utility of cats naturally co-infected with retroviruses as a model to investigate the impact of FV on immunocompromised mammalian hosts.
has issue date	2018-12-11(xsd:dateTime)
bibo:doi	10.3390/v10120702
bibo:pmid	30544924
has license	cc-by
sha1sum (hex)	e620067ec156a1fc9e5b28aaf66b38dd08815df8
schema:url	https://doi.org/10.3390/v10120702
resource representing a document's title	Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats
has PubMed Central identifier	PMC6315984
has PubMed identifier	30544924
schema:publication	Viruses
resource representing a document's body	covid:e620067ec156a1fc9e5b28aaf66b38dd08815df8#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e620067ec156a1fc9e5b28aaf66b38dd08815df8
is schema:about of	named entity 'FeLV' named entity 'cats' named entity 'pathogenicity' named entity 'supports' named entity 'serologically' named entity 'study' named entity 'disease' named entity 'Feline' named entity '28P' named entity 'ALLOWS' named entity 'FVS' named entity 'LOG10' named entity 'MEASURE' named entity 'PATHOGENIC' named entity '0.003' named entity 'SUMMARY' named entity 'REGRESSIVE' named entity 'DETECTABLE' named entity 'HOST' named entity 'DNA' named entity 'CAUSE' named entity 'USING' named entity 'INFECTION' named entity 'EVIDENCE OF' named entity 'COLLECTED' named entity 'RESULTS' named entity 'TRANSMISSION' named entity 'UTILITY' named entity 'ANEMIA' named entity 'METHODS' named entity 'TESTED FOR' named entity 'IMMUNOCOMPROMISED' named entity 'CO-INFECTION' named entity 'MODE' named entity 'DISEASE' named entity 'SALIVA' named entity 'POTENTIAL' named entity 'EVALUATION' named entity 'MONO' named entity 'SAMPLES' named entity 'TO INVESTIGATE' named entity 'REPORTED' named entity 'PREVIOUS' named entity 'DETECT' named entity 'RETROVIRUSES' named entity 'CO-INFECTION' named entity 'IMPACT' named entity 'INTERACT' named entity 'TO DETECT' named entity 'PROGRESSIVE' named entity 'CATS' named entity 'EPIDEMIOLOGY' named entity 'EXTRACTED' named entity 'MEDIAN' covid:arg/e620067ec156a1fc9e5b28aaf66b38dd08815df8 named entity 'MAMMALIAN' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'PCR' named entity 'CATS' named entity 'DID' named entity 'FEATURES' named entity 'CLINICAL' named entity 'FELINE FOAMY VIRUS' named entity 'QPCR' named entity 'USED' named entity 'LOWER' named entity 'STUDY' named entity 'PERFORMED' named entity 'SWABS' named entity 'PLASMA'

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