About: Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Creator	Kissoon, Niranjan Alhazzani, Waleed De Luca, Daniele Carrol, Enitan Faust, Saul Javouhey, Etienne Maclaren, Graeme Nguyen, Trung Peters, Mark Randolph, Adrienne Weiss, Scott Cruz, Andrea Schlapbach, Luregn Tasker, Robert Wong, Hector Flori, Heidi Carroll, Christopher Hall, Mark Wolf, Joshua Brierley, Joe Carcillo, Joseph Cheifetz, Ira Deep, Akash Kneyber, Martin Mehta, Nilesh Møller, Morten Nadel, Simon Newth, Christopher Nunnally, Mark Oliveira, De Ranjit, Suchitra Tissieres, Pierre Zimmerman, Jerry Agus, Michael Argent, Andrew Choong, Karen Parker, Margaret Cies, Jeffry Flauzino, Claudio Inwald, David Ishimine, Paul Joosten, Koen Joshi, Poonam Karam, Oliver Lemson, Joris Nishisaki, Akira Paul, Raina Romer, Lewis Scott, Halden Verger, Judy Tume, Lyvonne Williams, Eric
Source	PMC
abstract	OBJECTIVES: To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. DESIGN: A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international meetings (for those panel members attending the conference), and a stand-alone meeting was held for all panel members in November 2018. A formal conflict-of-interest policy was developed at the onset of the process and enforced throughout. Teleconferences and electronic-based discussion among the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. METHODS: The panel consisted of six subgroups: recognition and management of infection, hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence, statistically summarized the evidence, and then assessed the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. We used the evidence-to-decision framework to formulate recommendations as strong or weak, or as a best practice statement. In addition, “in our practice” statements were included when evidence was inconclusive to issue a recommendation, but the panel felt that some guidance based on practice patterns may be appropriate. RESULTS: The panel provided 77 statements on the management and resuscitation of children with septic shock and other sepsis-associated organ dysfunction. Overall, six were strong recommendations, 49 were weak recommendations, and nine were best-practice statements. For 13 questions, no recommendations could be made; but, for 10 of these, “in our practice” statements were provided. In addition, 52 research priorities were identified. CONCLUSIONS: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction provide a foundation for consistent care to improve outcomes and inform future research.
has issue date	2020-02-07(xsd:dateTime)
bibo:doi	10.1007/s00134-019-05878-6
bibo:pmid	32030529
has license	no-cc
sha1sum (hex)	e5e637c0e07f09166df905432f83d86c2fa29ec2
schema:url	https://doi.org/10.1007/s00134-019-05878-6
resource representing a document's title	Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
has PubMed Central identifier	PMC7095013
has PubMed identifier	32030529
schema:publication	Intensive Care Med
resource representing a document's body	covid:e5e637c0e07f09166df905432f83d86c2fa29ec2#body_text
is schema:about of	named entity 'organ dysfunction' named entity 'Surviving sepsis campaign' named entity 'organ dysfunction' named entity 'sepsis' named entity 'septic shock' named entity 'septic shock' named entity 'antimicrobial therapy' named entity 'septic shock' named entity 'sepsis' named entity 'sepsis' named entity 'coagulopathy' named entity 'infection' named entity 'septic shock' named entity '2.2' named entity 'PICU' named entity 'sepsis' named entity 'pathogens' named entity 'antimicrobials' named entity 'minute ventilation' named entity 'whey protein' named entity 'high-risk' named entity 'United States' named entity 'Fever' named entity 'infection' named entity 'physiologic response' named entity 'infection' named entity 'hepatomegaly' named entity 'epidemiology' named entity 'vasomotor tone' named entity 'drug therapy'

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