About: Phylogenetic analysis of human coronavirus NL63 circulating in Italy

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About: Phylogenetic analysis of human coronavirus NL63 circulating in Italy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phylogenetic analysis of human coronavirus NL63 circulating in Italy
Creator	Puro, V Gerna, G Capobianchi, M Cappiello, G Lauria, F Minosse, C Schifano, E Selleri, M Spanò, A Zaniratti, Campanini, G Gualano, G
topic	covid:e5d97f7b63a27580754be9bb994e44c6ff2aa8c4#this
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Five known human coronaviruses infect the human respiratory tract: HCoV-OC43, HCoV-229E, SARS-CoV, HCoV-NL63 and HCoV-HKU1. OBJECTIVES: To evaluate the prevalence of HCoV-NL63 in hospitalized adult patients and to perform molecular characterization of Italian strains. STUDY DESIGN: HCoV-NL63 was sought by RT-PCR in 510 consecutive lower respiratory tract (LRT) samples, collected from 433 Central-Southern Italy patients over a 1-year period. Phylogenetic analysis was performed by partial sequencing of S and ORF1a. Additional S sequences from Northern Italy were included in the phylogenetic trees. RESULTS: HCoV-NL63 was detected in 10 patients (2.0%) with symptomatic respiratory diseases, mainly during winter. Phylogenetic analysis indicated a certain degree of heterogeneity in Italian isolates. The ORF1a gene clustering in phylogenetic trees did not match with that of the S gene. CONCLUSIONS: As observed by others, HCoV-NL63 is often associated with another virus. Phylogenetic characterization of HCoV-NL63 circulating in Italy indicates that this virus circulates as a mixture of variant strains, as observed in other countries.
has issue date	2008-07-03(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2008.04.015
bibo:pmid	18602337
has license	no-cc
sha1sum (hex)	e5d97f7b63a27580754be9bb994e44c6ff2aa8c4
schema:url	https://doi.org/10.1016/j.jcv.2008.04.015
resource representing a document's title	Phylogenetic analysis of human coronavirus NL63 circulating in Italy
has PubMed Central identifier	PMC7108392
has PubMed identifier	18602337
schema:publication	J Clin Virol
resource representing a document's body	covid:e5d97f7b63a27580754be9bb994e44c6ff2aa8c4#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/e5d97f7b63a27580754be9bb994e44c6ff2aa8c4
is schema:about of	named entity 'prevalence' named entity 'human' named entity 'LRT' named entity 'HUMAN CORONAVIRUS NL63' named entity 'DID' named entity 'SOUTHERN' named entity 'COLLECTED' named entity 'RESPIRATORY DISEASES' named entity 'SAMPLES' named entity 'NORTHERN' named entity 'BACKGROUND' named entity 'VIRUS' named entity 'HCOV-NL63' named entity 'CHARACTERIZATION' named entity 'PREVALENCE' named entity 'VARIANT' named entity 'WINTER' covid:arg/e5d97f7b63a27580754be9bb994e44c6ff2aa8c4 named entity 'DETECTED' named entity 'COUNTRIES' named entity 'INDICATED' named entity 'CERTAIN' named entity 'PHYLOGENETIC ANALYSIS' named entity 'CIRCULATING' named entity 'ITALY' named entity '510' named entity 'ADULT' named entity 'MOLECULAR' named entity 'RESPIRATORY TRACT' named entity 'RT-PCR' named entity 'MATCH' named entity 'SYMPTOMATIC' named entity 'PATIENTS' named entity 'SARS-COV' named entity 'HCOV-OC43' named entity 'ASSOCIATED WITH' named entity 'CONSECUTIVE' named entity 'HCOV-229E' named entity 'TREES' named entity 'HUMAN' named entity 'CLUSTERING' named entity 'STUDY DESIGN' named entity 'PHYLOGENETIC ANALYSIS' named entity 'INFECT' named entity 'KNOWN' named entity 'ADDITIONAL' named entity 'ITALIAN' named entity 'GENE' named entity 'HOSPITALIZED' named entity 'OBSERVED' named entity '282' named entity 'CIRCULATING' named entity 'EVALUATE' named entity 'CONCLUSIONS' named entity 'DEGREE' named entity 'ITALY' named entity 'MIXTURE' named entity 'INCLUDED' named entity 'CENTRAL' named entity 'HCOV-HKU1' named entity 'ISOLATES' named entity 'SEQUENCING' named entity 'CORONAVIRUSES' named entity 'RESULTS' named entity 'PERIOD' named entity 'STRAINS' named entity 'LOWER RESPIRATORY TRACT' named entity 'HETEROGENEITY'

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