About: Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease
Creator	Iskander, John Ashraf, Mirette Hafez, Nada Hozaien, Rafeef Ismail, Habiba-Allah Kamel, Aya Saeed, Rana Youssef, Nourhan Menshawey, Esraa Abuzeid, Nadeen Ali, Salma Arsanyous, Mariem Ayad, Aya Kamel, Dina Khalil, Ayah Kotb, Basma Mansour, Mina Osman, Ibrahim Rashad, Lara Sefein, Fady Taha, Farah Waheed, Dina Abdelazeam, Aisha Abdelhameed, Manal Abdelsalam, Mahmoud-Nashaat Fakhry Abdelmassih, Antoine Gamal Hafez, Nouran Shershaby, Meryam Wakil, Lama
source	PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of an emerging pediatric multi-inflammatory syndrome mimicking Kawasaki disease (KD). MAIN BODY: This report reveals that coronaviridae were implicated in induction of several post-infectious vasculitides, namely, KD, AHEI, and HSP. This occurs in genetically susceptible individuals to vascular inflammation. Shared genetic susceptibilities between KD and CoV include genes encoding for CD 40, HLAB-15:03, and ACE. This leads to augmented inflammation with hypersecretion of cytokines especially IL-6. CONCLUSION: The revealed relationships between KD and CoV can help to predict the risk of KD in COVID-19 patients through screening levels of upregulated cytokines. It might also signify that classic treatment of KD with IVIG might need to be replaced with anti-cytokine therapy in COVID-19 patients.
has issue date	2020-07-01(xsd:dateTime)
bibo:doi	10.1186/s43054-020-00029-9
has license	cc-by
sha1sum (hex)	e5cfeb83b63d08f53205ef3eca3fc760d04e568f
schema:url	https://doi.org/10.1186/s43054-020-00029-9
resource representing a document's title	Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease
has PubMed Central identifier	PMC7358563
schema:publication	Egypt Pediatric Association Gaz
resource representing a document's body	covid:e5cfeb83b63d08f53205ef3eca3fc760d04e568f#body_text
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