About: Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children

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About: Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children
Creator	Althaus, Thomas Chotivanich, Kesinee Hanboonkunupakarn, Borimas Pukrittayakamee, Sasithon Thaipadungpanit, Janjira Blacksell, Stuart Lim, Chae Jittamalaid, Podjanee Kyaw, Myat May, Win Thein, Khin
Source	PMC
abstract	Glucose-6-phosphate dehydrogenase (G6PD) deficiency may affect the clinical presentation of dengue due to the altered redox state in immune cells. We aimed to determine the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. A cross-sectional study was conducted among paediatric patients aged 2–13 years with dengue in Yankin Children Hospital, Myanmar. One hundred and ninety-six patients positive for dengue infection, as determined via PCR or ELISA, were enrolled. Dengue severity was determined according to the 2009 WHO classification guidelines. Spectrophotometric assays determined G6PD levels. The adjusted median G6PD value of males in the study population was used to define various cut-off points according to the WHO classification guidelines. G6PD genotyping for Mahidol, Kaiping and Mediterranean mutations was performed for 128 out of 196 samples by real-time multiplex PCR. 51 of 196 (26.0%) patients had severe dengue. The prevalence of G6PD phenotype deficiency (< 60% activity) in paediatric patients was 14.8% (29/196), specifically, 13.6% (14/103) in males and 16.2% (15/93) in females. Severe deficiency (< 10% activity) accounted for 7.1% (14/196) of our cohort, occurring 11.7% (12/103) in males and 2.2% (2/93) in females. Among 128 samples genotyped, the G6PD gene mutations were detected in 19.5% (25/128) of patients, with 20.3% (13/ 64) in males and 18.8% (12/64) in females. The G6PD Mahidol mutation was 96.0% (24/25) while the G6PD Kaiping mutation was 4.0% (1/25). Severe dengue was not associated with G6PD enzyme deficiency or presence of the G6PD gene mutation. Thus, no association between G6PD deficiency and dengue severity could be detected. Trial registration: The study was registered following the WHO International Clinical Trials Registry Platform (WHO-ICTRP) on Thai Clinical Trials Registry (TCTR) website, registration number # TCTR20180720001
has issue date	2019-01-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0209204
bibo:pmid	30601843
has license	cc-by
sha1sum (hex)	e5c06914d0daee6e881665b23adca340d0a6271a
schema:url	https://doi.org/10.1371/journal.pone.0209204
resource representing a document's title	Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children
has PubMed Central identifier	PMC6314580
has PubMed identifier	30601843
schema:publication	PLoS One
resource representing a document's body	covid:e5c06914d0daee6e881665b23adca340d0a6271a#body_text
is schema:about of	named entity 'GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY' named entity 'mutations' named entity 'phenotype' named entity 'enzyme' named entity 'determine' named entity 'patients' named entity 'activity' named entity 'real-time' named entity 'median' named entity 'activity' named entity 'mutations' named entity 'POSITIVE FOR' named entity 'MUTATION' named entity 'MEDITERRANEAN' named entity 'WHO CLASSIFICATION' named entity 'CHILDREN' named entity 'DENGUE INFECTION' named entity 'CLINICAL PRESENTATION' named entity 'PAEDIATRIC' named entity '14.8' named entity '60%' covid:arg/e5c06914d0daee6e881665b23adca340d0a6271a named entity 'COHORT' named entity 'ENZYME DEFICIENCY' named entity '16.2' named entity 'MALES' named entity 'YEARS' named entity 'HOSPITAL' named entity 'ACCORDING' named entity 'FEMALES' named entity 'PHENOTYPE' named entity 'IMMUNE CELLS' named entity 'MEDIAN' named entity 'IMPACT' named entity 'DENGUE INFECTION' named entity 'PCR' named entity 'NINETY-SIX' named entity 'ALTERED' named entity '282' named entity 'REDOX STATE' named entity 'AFFECT' named entity 'SEVERITY' named entity '10%' named entity 'CHILDREN' named entity 'LEVELS' named entity 'OUR' named entity 'SAMPLES' named entity 'VALUE' named entity 'GUIDELINES' named entity 'ELISA' named entity 'GENOTYPING' named entity 'MULTIPLEX PCR' named entity 'G6PD DEFICIENCY' named entity 'POINTS' named entity 'PATIENTS' named entity 'SEVERE DENGUE' named entity 'ACTIVITY' named entity 'DEFICIENCY' named entity 'CROSS-SECTIONAL STUDY' named entity '196' named entity 'MYANMAR' named entity 'DETECTED' named entity 'PREVALENCE' named entity 'MUTATIONS' named entity 'DUE TO' named entity 'GENE MUTATION' named entity '13.6' named entity '20.3' named entity '19.5' named entity 'DENGUE' named entity 'GLUCOSE-6-PHOSPHATE DEHYDROGENASE'

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