About: How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
Creator	Giaquinto, Carlo Barbieri, Elisa Donà, Daniele Minotti, Chiara Tirelli, Francesca Pharmd, Elisa
Source	Elsevier; Medline; PMC
abstract	Abstract Objectives SARS-CoV-2 infection has now a global resonance. Data on how COVID-19 is affecting immunocompromised patients are however few. With our study we aimed to systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population. Methods A systematic review of literature was carried out to identify relevant articles, searching the EMBASE, Medline, and Google Scholar databases. Studies reporting data on pre-defined outcomes and related to immunosuppressed adults and children with SARS-CoV-2 were included. Results Sixteen relevant articles were identified with 110 immunosuppressed patients, mostly presenting cancer, along with transplantation and immunodeficiency. Cancer was more often associated with a more severe course, but not necessarily with a bad prognosis. Our data show that both children and adults with immunosuppression seem to have a favorable disease course, as compared to the general population. Conclusion Immunosuppressed patients with COVID-19 seem to be few in relation to the overall figures, and to present a favorable outcome as compared to other comorbidities. This might be explained by a hypothetical protective role of a weaker immune response, determining a milder disease presentation and thus underdiagnosis. Nevertheless, surveillance on this special population should be encouraged.
has issue date	2020-04-23(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2020.04.026
bibo:pmid	32335173
has license	els-covid
sha1sum (hex)	e5b2b16606248c9c9640dda13d0c0b1dfe56e37b
schema:url	https://doi.org/10.1016/j.jinf.2020.04.026
resource representing a document's title	How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review
has PubMed Central identifier	PMC7179496
has PubMed identifier	32335173
schema:publication	J Infect
resource representing a document's body	covid:e5b2b16606248c9c9640dda13d0c0b1dfe56e37b#body_text
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