About: Human B cell clonal expansion and convergent antibody responses to SARS CoV-2

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Human B cell clonal expansion and convergent antibody responses to SARS CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human B cell clonal expansion and convergent antibody responses to SARS CoV-2
Creator	Yang, Fan Rogers, Angela Lee, Ji-Yeun Chang, Jardetzky, Theodore Kim, Peter Pinsky, Benjamin Blish, Catherine Boyd, Scott Daniel, Bence Hoh, Ramona Jackson, Katherine Najeeb, Javaria Nielsen, Sandra Otrelo-Cardoso, Ana Rustagi, Arjun Röltgen, Katharina Satpathy, Ansuman Stevens, Bryan Wang, Taia Yost, Kathryn
Source	BioRxiv; Medline; PMC
abstract	During virus infection B cells are critical for the production of antibodies and protective immunity. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify extensive convergence of antibody sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.
has issue date	2020-07-09(xsd:dateTime)
bibo:doi	10.1101/2020.07.08.194456
bibo:pmid	32676593
has license	cc-by-nc-nd
sha1sum (hex)	e583d2c9a06c2ee41fdfe138d63d26c326798951
schema:url	https://doi.org/10.1101/2020.07.08.194456
resource representing a document's title	Human B cell clonal expansion and convergent antibody responses to SARS CoV-2
has PubMed Central identifier	PMC7359515
has PubMed identifier	32676593
schema:publication	bioRxiv
resource representing a document's body	covid:e583d2c9a06c2ee41fdfe138d63d26c326798951#body_text
is schema:about of	named entity 'virus' named entity 'specific' named entity 'identify' named entity 'expressing' named entity 'responses' named entity 'B cell' covid:arg/e583d2c9a06c2ee41fdfe138d63d26c326798951 named entity 'responses' named entity 'spillover' named entity 'convergent' named entity 'patients' named entity 'IgG' named entity 'SARS-CoV-2' named entity 'zoonotic' named entity 'SARS-CoV' named entity 'polyclonal response' named entity 'production' named entity 'subset' named entity 'rapidly' named entity 'gene' named entity 'SARS-CoV-2' named entity 'subset' named entity 'cross-reactive' named entity 'IgA' named entity 'somatic hypermutation' named entity 'antibody' named entity 'polyclonal' named entity 'receptor' named entity 'COVID' named entity 'clonal expansion' named entity 'SARS-CoV' named entity 'weeks' named entity 'COVID-19' named entity 'coronavirus disease 2019' named entity 'IGHV' named entity 'IGH' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'gDNA' named entity '5.8' named entity 'IgA1' named entity 'SARS-Cov-2' named entity 'influenza virus' named entity 'High-throughput DNA sequencing' named entity 'mutation' named entity 'COVID-19' named entity 'aromaticity' named entity 'SARS-CoV-2' named entity 'IGHV' named entity 'IGHV' named entity 'ANOVA' named entity 'IGH' named entity 'gDNA' named entity 'proliferation of cells' named entity 'IgG1' named entity 'isotypes' named entity '10x Genomics' named entity 'sequenced' named entity 'SARS-CoV' named entity 'Tukey's HSD' named entity 'IGH' named entity 'SARS-CoV-2'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software