About: Vaccinia virus produces late mRNAs by discontinuous synthesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vaccinia virus produces late mRNAs by discontinuous synthesis
Creator	Bertholet, Christine Van Meir, Erwin Wittek, Riccardo Ten Heggeler-Bordier, Beatrice
Source	Elsevier; Medline; PMC
abstract	Abstract We describe the unusual structure of a vaccinia virus late mRNA. In these molecules, the protein-coding sequences of a major late structural polypeptide are preceded by long leader RNAs, which in some cases are thousands of nucleotides long. These sequences map to different regions of the viral genome and in one instance are separated from the late gene by more than 100 kb of DNA. Moreover, the leader sequences map either upstream or downstream of the late gene, are transcribed from either DNA strand, and are fused to the late gene coding sequence via a poly(A) stretch. This demonstrates that vaccinia virus produces late mRNAs by tagging the protein-coding sequences onto the 3′ end of other RNAs.
has issue date	1987-07-17(xsd:dateTime)
bibo:doi	10.1016/0092-8674(87)90211-x
bibo:pmid	3036368
has license	els-covid
sha1sum (hex)	e54c0a07b76e9b5ae145e81a0b44cde27b923f76
schema:url	https://doi.org/10.1016/0092-8674%2887%2990211-x
resource representing a document's title	Vaccinia virus produces late mRNAs by discontinuous synthesis
has PubMed Central identifier	PMC7133321
has PubMed identifier	3036368
schema:publication	Cell
resource representing a document's body	covid:e54c0a07b76e9b5ae145e81a0b44cde27b923f76#body_text
is schema:about of	named entity 'genome' named entity 'fused' named entity 'DNA' named entity 'UNUSUAL' named entity 'INSTANCE' named entity 'DOWNSTREAM' named entity 'TRANSCRIBED' named entity 'SEPARATED FROM' named entity 'EITHER' named entity 'MRNA' named entity 'TAGGING' named entity 'SYNTHESIS' named entity 'POLYPEPTIDE' named entity 'VACCINIA VIRUS' named entity 'DISCONTINUOUS' named entity 'LATE' named entity 'MRNAS' named entity 'MAP' named entity 'PROTEIN-CODING' named entity 'PRECEDED' named entity 'FUSED TO' named entity 'VIRAL GENOME' named entity 'DIFFERENT' named entity 'MOLECULES' named entity 'REGIONS' named entity 'THESE' named entity 'DNA' named entity 'STRUCTURAL' named entity 'DESCRIBE' named entity 'A MAJOR' named entity 'A POLY' named entity '28A' named entity 'MORE THAN' named entity 'SEQUENCES' named entity 'CASES' named entity 'LONG' named entity '100' named entity 'STRETCH' named entity 'NUCLEOTIDES' named entity 'LATE' named entity 'UPSTREAM' named entity 'END' named entity 'CODING SEQUENCE' named entity 'STRAND' named entity 'STRUCTURE' named entity 'GENE' named entity 'VACCINIA VIRUS' named entity 'transcribed' named entity 'gene' named entity 'strand' named entity 'sequences' named entity 'long' named entity 'coding sequence' named entity 'map' named entity 'gene' named entity 'protein-coding sequences' named entity 'RNAa' named entity 'mRNAs' named entity 'single-stranded' named entity 'codon' named entity 'tRNA' named entity 'double-stranded' named entity 'gene' named entity 'Primer Extension' named entity 'cDNA' named entity 'nucleotide' named entity 'pH 7' named entity 'nucleotides' named entity 'RNAs' named entity 'polypeptide' named entity 'enzyme' named entity 'electron microscopy' named entity 'hybridization' named entity 'mRNA' named entity 'RNAs' named entity 'vaccinia virus' named entity 'cDNAs' named entity '32P'

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