About: Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses
Creator	Tsurudome, Masato Ghildyal, Reena Heydet, Deborah Irie, Takashi Adachi, Akio Gahan, Michelle Momose, Fumitaka Walker, Erin Wulan, Wahyu
source	Medline; PMC
abstract	Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.
has issue date	2015-06-02(xsd:dateTime)
bibo:doi	10.3389/fmicb.2015.00553
bibo:pmid	26082769
has license	cc-by
sha1sum (hex)	e546530d3c2507a91afb8ed59c87cac0c8b501da
schema:url	https://doi.org/10.3389/fmicb.2015.00553
resource representing a document's title	Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses
has PubMed Central identifier	PMC4451415
has PubMed identifier	26082769
schema:publication	Front Microbiol
resource representing a document's body	covid:e546530d3c2507a91afb8ed59c87cac0c8b501da#body_text
is schema:about of	named entity 'nucleocapsid' named entity 'viruses' named entity 'evidence' named entity 'nucleolus' named entity 'antiviral' named entity 'journal' named entity 'successful' named entity 'viral replication' named entity 'nucleocapsid' named entity 'nucleocapsid' named entity 'target' named entity 'cytoplasmic' named entity 'antiviral drugs' named entity 'Nucleocapsid proteins' named entity 'RNA viruses' named entity 'cytoplasm' named entity 'nucleocapsid proteins' named entity 'therapeutic strategies' named entity 'infection' named entity 'nucleus' named entity 'nuclear localization' named entity 'antiviral' named entity 'RNA viruses' named entity 'RNA viruses' named entity 'nucleocapsid proteins' named entity 'Microbiology' named entity 'nucleocapsid proteins' named entity 'regulate transcription' named entity 'virus replication' named entity 'viral particle' named entity 'Dengue' named entity 'nuclear transport' named entity 'nucleocapsid protein' named entity 'PRRSV' named entity 'de Melo' named entity 'nuclear envelope' named entity 'ribosomal proteins' named entity 'nucleocapsid proteins' named entity 'dimerization' named entity 'pathogenesis' named entity 'Coronavirus' named entity 'Nucleocapsid proteins' named entity 'nucleic acid' named entity 'negative strand RNA viruses' named entity 'Paramyxovirus' named entity 'RNA' named entity 'Measles virus' named entity 'NSV' named entity 'ISG' named entity 'Nucleocapsid proteins' named entity 'transcription factors' named entity 'NLS' named entity 'Arginine' named entity 'encapsidation' named entity 'SARS-CoV' named entity 'nucleocapsid protein' named entity 'nuclear localization' named entity 'importin-α' named entity 'mice' named entity 'IFN' named entity 'protein' named entity 'cellular processes' named entity 'HCV' named entity 'nucleocapsid protein' named entity 'SARS-CoV' named entity 'Rhabdoviridae' named entity 'Paramyxoviridae' named entity 'Coronavirus' named entity 'nuclear translocation' named entity 'capsid' named entity 'IFN' named entity 'antiviral' named entity 'nucleocapsid protein'

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