About: Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins
Creator	Ding, Shilei Liang, Chen Liu, Shan-Lu Pan, Qinghua Zheng, Yi-Min Qian, Jin Wang, Yimeng Le Duff, Yann
Source	Elsevier; Medline; PMC
abstract	Abstract Interferon-induced transmembrane (IFITM) proteins inhibit the entry of a large number of viruses. Not surprisingly, many viruses are refractory to this inhibition. In this study, we report that different strains of HIV and SIV are inhibited by human IFITM proteins to various degrees, with SIV of African green monkeys (SIVAGM) being mostly restricted by human IFITM2. Interestingly, SIVAGM is as much inhibited by human IFITM2 as by IFITM3 of its own host African green monkeys. Our data further demonstrate that the entry of SIVAGM is impaired by human IFITM2 and that this inhibition is overcome by the cholesterol-binding compound amphotericin B that also overcomes IFITM inhibition of influenza A viruses. These results suggest that IFITM proteins exploit similar mechanisms to inhibit the entry of both pH-independent primate lentiviruses and the pH-dependent influenza A viruses.
has issue date	2015-01-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2014.10.015
bibo:pmid	25463599
has license	els-covid
sha1sum (hex)	e4c0846438059d270c635e3aeadb06828b4dfa3b
schema:url	https://doi.org/10.1016/j.virol.2014.10.015
resource representing a document's title	Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins
has PubMed Central identifier	PMC4581848
has PubMed identifier	25463599
schema:publication	Virology
resource representing a document's body	covid:e4c0846438059d270c635e3aeadb06828b4dfa3b#body_text
is schema:about of	named entity 'INTERFERON' named entity 'INDUCED' named entity 'PRIMATE' named entity 'TRANSMEMBRANE PROTEINS' named entity 'LENTIVIRUSES' named entity 'INHIBITED' named entity 'transmembrane proteins' named entity 'lentiviruses' named entity 'CXCR4' named entity 'DMEM' named entity 'cell line' named entity 'SARS' named entity 'puromycin' named entity 'ifitm3' named entity 'penicillin' named entity 'SIV' named entity 'SIV' named entity 'Ebola' named entity 'amino acid' named entity 'acute infection' named entity 'viruses' named entity 'lymphocytic choriomeningitis virus' named entity 'SIV' named entity 'SIV' named entity 'MLV' named entity 'amino acid' named entity 'SIV' named entity 'assay' named entity 'lipid bilayer' named entity 'gene' named entity 'transduced' named entity 'endocytosis' named entity 'VAPA' named entity 'virus entry' named entity 'SIV' named entity 'infection' named entity 'osteoblasts' named entity 'adaptor protein' named entity 'viruses' named entity 'SIV' named entity 'GenBank' named entity 'Beckman Coulter' named entity 'NIH' named entity 'MLV' named entity 'phosphate' named entity 'endogenous' named entity 'polybrene' named entity 'COS-7' named entity 'SIV' named entity 'endocytosis' named entity 'rhesus macaques' named entity 'endosomal membrane' named entity 'SIV' named entity 'type I interferon' named entity 'virus entry' named entity 'LASV' named entity 'influenza' named entity 'plasmid DNA' named entity 'RNA' named entity 'kidney' named entity 'cDNA' named entity 'viruses' named entity 'vesicular stomatitis virus' named entity 'refractory' named entity 'reverse transcriptase' named entity 'chimpanzee' named entity 'SIV' named entity 'flaviviruses' named entity 'sodium dodecyl sulfate' named entity 'GE Healthcare' named entity 'HIV' named entity 'IFITM3' named entity 'retroviruses' named entity 'statistical significance'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software