About: Preparation and Antibacterial Activity Evaluation of 18-β-glycyrrhetinic Acid Loaded PLGA Nanoparticles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Preparation and Antibacterial Activity Evaluation of 18-β-glycyrrhetinic Acid Loaded PLGA Nanoparticles
Creator	Amini, Mohsen Atyabi, Fatemeh Darvishi, Behrad Dinarvand, Rassoul Kamalinia, Golnaz Maghazei, Shahab Manoochehri, Saeed Samadi, Nasrin Mostafavi, Seyyed
Source	Medline; PMC
abstract	The aim of the present study was to formulate poly (lactide-co-glycolide) (PLGA) nanoparticles loaded with 18-β-glycyrrhetinic acid (GLA) with appropriate physicochemical properties and antimicrobial activity. GLA loaded PLGA nanoparticles were prepared with different drug to polymer ratios, acetone contents and sonication times and the antibacterial activity of the developed nanoparticles was examined against different gram-negative and gram-positive bacteria. The antibacterial effect was studied using serial dilution technique to determine the minimum inhibitory concentration of nanoparticles. Results demonstrated that physicochemical properties of nanoparticles were affected by the above mentioned parameters where nanoscale size particles ranging from 175 to 212 nm were achieved. The highest encapsulation efficiency (53.2 ± 2.4%) was obtained when the ratio of drug to polymer was 1:4. Zeta potential of the developed nanoparticles was fairly negative (-11±1.5). In-vitro release profile of nanoparticles showed two phases: an initial phase of burst release for 10 h followed by a slow release pattern up to the end. The antimicrobial results revealed that the nanoparticles were more effective than pure GLA against P. aeuroginosa, S. aureus and S. epidermidis. This improvement in antibacterial activity of GLA loaded nanoparticles when compared to pure GLA may be related to higher nanoparticles penetration into infected cells and a higher amount of GLA delivery in its site of action. Herein, it was shown that GLA loaded PLGA nanoparticles displayed appropriate physicochemical properties as well as an improved antimicrobial effect.
has issue date	2015-01-01(xsd:dateTime)
bibo:pmid	25901144
has license	cc-by
sha1sum (hex)	e4bc8603739ef592b4ce5c2a3b92abd82a2a13ef
resource representing a document's title	Preparation and Antibacterial Activity Evaluation of 18-β-glycyrrhetinic Acid Loaded PLGA Nanoparticles
has PubMed Central identifier	PMC4403053
has PubMed identifier	25901144
schema:publication	Iran J Pharm Res
resource representing a document's body	covid:e4bc8603739ef592b4ce5c2a3b92abd82a2a13ef#body_text
is schema:about of	named entity 'EVALUATION' named entity 'activity' named entity 'initial' named entity 'higher' named entity 'study' named entity 'GLA' named entity 'improved' named entity 'physicochemical' named entity 'Evaluation' named entity 'Preparation' named entity 'GLYCYRRHETINIC ACID' named entity 'GLYCOLIDE' named entity 'BURST' named entity 'ZETA POTENTIAL' named entity 'HIGHER' named entity '3A4' named entity 'GLA' named entity 'RELATED' named entity 'DETERMINE' named entity 'UP TO' named entity 'PENETRATION' named entity '2.4' named entity 'S. EPIDERMIDIS' named entity 'GRAM-' named entity 'PHYSICOCHEMICAL PROPERTIES' named entity 'ANTIMICROBIAL' named entity 'MINIMUM INHIBITORY CONCENTRATION' named entity 'NANOPARTICLES' named entity 'TECHNIQUE' named entity 'TIMES' named entity 'RESULTS' named entity 'PLGA' named entity 'DISPLAYED' named entity 'NEGATIVE' named entity 'OBTAINED' named entity 'POLY' named entity 'SIZE' named entity 'INFECTED' named entity 'DELIVERY' named entity 'SITE OF' named entity 'AFFECTED' named entity 'IMPROVED' named entity 'ANTIBACTERIAL' named entity 'SERIAL' named entity 'ANTIMICROBIAL ACTIVITY' named entity 'ITS' named entity 'PURE' named entity 'IMPROVEMENT' named entity 'RATIOS' named entity 'PROFILE' named entity 'END' named entity 'COMPARED' named entity 'CELLS' named entity '212' named entity 'CONTENTS' named entity 'PHASES' named entity 'POLYMER' named entity 'PREPARATION' named entity 'NANOPARTICLES' named entity 'IN-VITRO' named entity 'ENCAPSULATION EFFICIENCY' named entity 'SLOW' named entity 'FOLLOWED BY' named entity 'B11' named entity 'ACTION' named entity 'GLYCYRRHETINIC ACID' named entity 'DILUTION' named entity 'DRUG' covid:arg/e4bc8603739ef592b4ce5c2a3b92abd82a2a13ef named entity 'RELEASE' named entity 'HIGHEST' named entity 'EFFECT' named entity 'ANTIBACTERIAL' named entity 'AIM' named entity 'PATTERN'

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