About: Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection

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About: Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection
Creator	Burwinkel, Michael Blohm, Ulrike Chai, Weidong Janczyk, Pawel Osterrieder, Nikolaus Twardziok, Sven Wang, Zhenya
Source	Medline; PMC
abstract	BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important infectious agents for the swine industry worldwide. Zinc (Zn) salts, which are widely used as a dietary supplement in swine nutrition, have shown antiviral effects in vitro as well as in vivo. The purpose of this study was to determine the influence of dietary zinc oxide supplementation on vaccination and challenge infection with PRRSV. FINDINGS: The clinical course of PRRS and the success of vaccination with an experimental inactivated vaccine were compared between animals receiving a conventional diet (50 ppm Zn, control group) and diets supplemented with Zn oxide (ZnO) at final Zn concentrations of 150 or 2,500 ppm. Pigs receiving higher dietary Zn levels showed a tendency towards higher neutralizing antibody levels after infection, while dietary Zn levels did not substantially influence the number of antiviral IFN-gamma secreting cells (IFN-gamma-SC) or percentages of blood immune cell subsets after infection. Finally, feeding higher dietary Zn levels reduced neither clinical symptoms nor viral loads. CONCLUSIONS: Our results suggest that higher levels of dietary ZnO do not have the potential to stimulate or modulate systemic immune responses after vaccination and heterologous PRRSV infection to an extent that could improve the clinical and virological outcome. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1743-422X-11-140) contains supplementary material, which is available to authorized users.
has issue date	2014-08-08(xsd:dateTime)
bibo:doi	10.1186/1743-422x-11-140
bibo:pmid	25103309
has license	cc-by
sha1sum (hex)	e488697a5a07d8a7077f4dae04f386ff038fba5b
schema:url	https://doi.org/10.1186/1743-422x-11-140
resource representing a document's title	Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection
has PubMed Central identifier	PMC4254400
has PubMed identifier	25103309
schema:publication	Virol J
resource representing a document's body	covid:e488697a5a07d8a7077f4dae04f386ff038fba5b#body_text
is schema:about of	named entity 'higher' named entity 'number' named entity 'worldwide' named entity 'substantial' named entity 'levels' named entity 'infection' named entity 'EFFECT' named entity 'CLINICAL SYMPTOMS' named entity '150' named entity 'SECRETING' named entity 'SYSTEMIC' named entity 'OXIDE' named entity 'IMMUNE CELL' named entity 'ANIMALS' named entity 'REDUCED' named entity 'PIGS' named entity 'CLINICAL COURSE' named entity 'DIETS' named entity 'NEITHER' named entity 'DIETARY SUPPLEMENT' named entity 'INFECTION' named entity 'INDUSTRY' named entity 'CONVENTIONAL' named entity 'STUDY' named entity 'VIRAL' named entity 'RECEIVING' named entity 'RESULTS' named entity 'DIETARY ZINC' named entity 'VIROLOGICAL' named entity 'PURPOSE' named entity 'INFLUENCE' named entity 'CHALLENGE' named entity 'NUMBER OF' named entity 'SALTS' named entity 'TENDENCY' named entity 'CONTROL GROUP' named entity 'DO NOT' named entity 'BLOOD' named entity 'FINDINGS' named entity 'ZINC' named entity 'IFN-GAMMA' named entity 'DIET' named entity 'VACCINATION' named entity 'CELLS' named entity 'CONCLUSIONS' named entity 'WORLDWIDE' named entity 'IMPORTANT' named entity 'EXTENT' named entity 'SWINE' named entity 'PRRS' named entity 'PPM' named entity 'HAVE' named entity 'DO NOT' named entity 'CLINICAL' named entity 'NEUTRALIZING ANTIBODY' named entity 'ANTIVIRAL' named entity 'EFFECTS' named entity 'FINAL' named entity 'ZINC OXIDE' named entity 'VACCINATION' named entity 'ONE OF' named entity 'NUTRITION' named entity 'DIETARY ZINC' named entity 'LEVELS' named entity 'INFECTION' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'BACKGROUND' named entity 'LEVELS' named entity 'HETEROLOGOUS' named entity 'POTENTIAL' named entity 'COMPARED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'CONCENTRATIONS' named entity 'IN VITRO' named entity 'SUPPLEMENTATION'

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