About: Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs
Creator	Fenoy, Soledad García-Presedo, Ignacio González-Warleta, Marta Mezo, Mercedes Rueda, Cristina Castro-Hermida, José Del Á Guila, Carmen
Source	Elsevier; Medline; PMC
abstract	Abstract The efficacy of the anti-inflammatory drug Bobel-24 against experimental infection by Cryptosporidium parvum was evaluated in neonatal lambs. The animals were treated by oral administration of the drug at 50 or 500mg/kg of body weight. The prophylactic/therapeutic treatment was started 4h before inoculation of the lambs with oocysts and was continued for eight consecutive days. The therapeutic treatment was initiated at the onset of diarrhoea, after confirmation of infection, and was continued for six consecutive days. Infection was monitored by daily examination of faecal samples from the first day until 30 days post-inoculation. The criteria considered in evaluating development of the infection and the drug activity were: oocyst shedding, presence of diarrhoea and weight gain at 15 and 30 days post-inoculation. Bobel-24 was effective as a prophylactic/therapeutic treatment at the lowest dose (50mg/kg of body weight); in the group treated with this dose of drug there was a longer prepatent period, a shorter patent period and a lower intensity of oocyst excretion than in the untreated control group, and the differences were all statistically significant (P <0.05). Moreover, one animal did not excrete oocysts, and two lambs had diarrhoea, for only 1 and 2 days. In the group treated with the higher dose of the drug, the diarrhoea lasted for a significantly shorter period (P <0.05) than in the untreated group.
has issue date	2008-08-17(xsd:dateTime)
bibo:doi	10.1016/j.vetpar.2008.05.012
bibo:pmid	18579312
has license	els-covid
sha1sum (hex)	e47debab6f4c7116b7dd0cfcc2ea5ac1e2ab5146
schema:url	https://doi.org/10.1016/j.vetpar.2008.05.012
resource representing a document's title	Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs
has PubMed Central identifier	PMC7131681
has PubMed identifier	18579312
schema:publication	Veterinary Parasitology
resource representing a document's body	covid:e47debab6f4c7116b7dd0cfcc2ea5ac1e2ab5146#body_text
is schema:about of	named entity 'group' named entity 'intensity' named entity 'group' named entity 'confirmation' named entity 'diarrhoea' named entity 'drug' named entity 'INFECTION' named entity 'UNTREATED' named entity 'CONSECUTIVE DAYS' named entity 'TREATED' named entity 'OOCYST' named entity 'PRESENCE OF' named entity 'SAMPLES' named entity 'DAY' named entity '28P' named entity 'ANIMAL' named entity 'DAYS' named entity 'EVALUATING' named entity '0.05' named entity 'DAILY' named entity 'POST' named entity 'INOCULATION' named entity 'CONSIDERED' named entity 'PERIOD' named entity 'HIGHER' named entity 'LAMBS' named entity 'MG%' named entity 'ACTIVITY' named entity 'CONFIRMATION OF' named entity 'LAMBS' named entity 'SHEDDING' named entity 'DIARRHOEA' named entity 'EXPERIMENTAL INFECTION' named entity 'NEONATAL' named entity 'ANTI-INFLAMMATORY DRUG' named entity 'CRYPTOSPORIDIOSIS' named entity 'BODY WEIGHT' named entity 'THERAPEUTIC' named entity 'CONTINUED' named entity 'EXCRETION' named entity 'ONSET OF' named entity 'TREATED WITH' named entity 'CRITERIA' named entity 'WAS A' named entity 'ANTI-INFLAMMATORY DRUG' named entity 'DID' named entity 'NEONATAL' named entity 'EXAMINATION' named entity 'TREATMENT' named entity 'WEIGHT GAIN' named entity 'INFECTION BY CRYPTOSPORIDIUM PARVUM' named entity 'ORAL ADMINISTRATION' named entity 'DEVELOPMENT' named entity 'FAECAL' named entity 'ANIMALS' named entity 'PROPHYLACTIC' named entity 'PATENT' named entity 'EVALUATED' named entity 'GROUP' named entity 'INTENSITY' named entity 'LOWER' named entity 'DOSE' named entity 'MONITORED' named entity '500' named entity 'ACTIVITY' named entity 'STARTED' named entity 'EFFECTIVE' named entity 'LOWEST' named entity 'EFFICACY' named entity 'STATISTICALLY SIGNIFICANT' named entity 'CONTROL GROUP' named entity 'DRUG' named entity 'OOCYSTS' covid:arg/e47debab6f4c7116b7dd0cfcc2ea5ac1e2ab5146 named entity 'dose'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software