About: Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus

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About: Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus
Creator	Kobasa, Darwyn Ranadheera, Charlene Coombs, Kevin
source	PMC
abstract	Previous transcriptomic analyses suggested that the 1918 influenza A virus (IAV1918), one of the most devastating pandemic viruses of the 20th century, induces a dysfunctional cytokine storm and affects other innate immune response patterns. Because all viruses are obligate parasites that require host cells for replication, we globally assessed how IAV1918 induces host protein dysregulation. We performed quantitative mass spectrometry of IAV1918-infected cells to measure host protein dysregulation. Selected proteins were validated by immunoblotting and phosphorylation levels of members of the PI3K/AKT/mTOR pathway were assessed. Compared to mock-infected controls, >170 proteins in the IAV1918-infected cells were dysregulated. Proteins mapped to amino sugar metabolism, purine metabolism, steroid biosynthesis, transmembrane receptors, phosphatases and transcription regulation. Immunoblotting demonstrated that IAV1918 induced a slight up-regulation of the lamin B receptor whereas all other tested virus strains induced a significant down-regulation. IAV1918 also strongly induced Rab5b expression whereas all other tested viruses induced minor up-regulation or down-regulation. IAV1918 showed early reduced phosphorylation of PI3K/AKT/mTOR pathway members and was especially sensitive to rapamycin. These results suggest the 1918 strain requires mTORC1 activity in early replication events, and may explain the unique pathogenicity of this virus.
has issue date	2018-06-02(xsd:dateTime)
bibo:doi	10.1016/j.ebiom.2018.05.027
bibo:pmid	29866590
has license	cc-by-nc-nd
sha1sum (hex)	e47398378aa4514d5d2669d9d378752ed75bd11c
schema:url	https://doi.org/10.1016/j.ebiom.2018.05.027
resource representing a document's title	Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus
has PubMed Central identifier	PMC6021456
has PubMed identifier	29866590
schema:publication	EBioMedicine
resource representing a document's body	covid:e47398378aa4514d5d2669d9d378752ed75bd11c#body_text
is schema:about of	named entity 'members' named entity 'levels' named entity 'transcription regulation' named entity 'up-regulation' named entity 'assess' named entity 'assessed' named entity 'replication' named entity 'mTORC1' named entity 'stable' named entity 'transcriptomic' named entity 'cells' named entity 'mTOR' named entity 'Influenza' named entity 'SIGNIFICANT' named entity 'IMMUNOBLOTTING' named entity 'MAPPED' named entity 'HOST CELLS' named entity 'POOR' named entity 'N170' named entity 'SENSITIVE TO RAPAMYCIN' named entity 'METHOD' named entity 'STRAIN' named entity 'INDUCED' named entity 'PURINE METABOLISM' named entity 'ALTERATIONS' named entity 'DOWN-REGULATION' named entity 'TESTED' named entity 'TRANSMEMBRANE RECEPTORS' named entity 'VALIDATED' named entity '1918' named entity 'OBLIGATE' named entity 'SUGGEST' named entity 'REDUCED' named entity 'CONTROLS' named entity 'SLIGHT' named entity 'PROTEIN SYNTHESIS' covid:arg/e47398378aa4514d5d2669d9d378752ed75bd11c named entity 'viruses' named entity 'induces' named entity 'suggested' named entity 'effector protein' named entity 'transmembrane receptors' named entity 'PI3K' named entity 'replication' named entity 'PI3K' named entity 'dysfunctional' named entity 'extents' named entity 'cells' named entity 'mapped' named entity 'lamin B receptor' named entity 'cells' named entity 'strains' named entity '1918 virus' named entity 'protein' named entity 'PI3K/AKT/mTOR pathway' named entity 'mRNA' named entity 'cytokine storm' named entity 'transmembrane receptors' named entity 'microarray' named entity 'A549' named entity 'rapamycin' named entity 'pathogenicity' named entity 'proteomic' named entity 'innate immune response' named entity 'influenza A virus' named entity 'PI3K/AKT/mTOR pathway' named entity 'up-regulation' named entity 'metabolism' named entity 'virus' named entity 'amino sugar' named entity 'viruses' named entity 'transcription regulation' named entity 'steroid biosynthesis' named entity 'by-nc-nd' named entity 'downregulation' named entity 'down-regulated' named entity 'Nup205' named entity 'LBR' named entity 'host response'

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