About: High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms
Creator	Angermair, Stefan Eckardt, Kai-Uwe Endres, Matthias Franke, Christiana Kreye, Jakob Prüss, Harald Treskatsch, Sascha Hosp, Jonas Audebert, Heinrich Dersch, Rick Ferse, Caroline Franke, Ploner, Christoph Reincke, Momsen Rocco, Andrea Sanchez-Sendin, Elisa Steinbrenner, Mirja Zickler, Daniel
Source	MedRxiv
abstract	COVID-19 intensive care patients occasionally develop neurological symptoms. The absence of SARS-CoV-2 in most cerebrospinal fluid (CSF) samples suggests the involvement of further mechanisms including autoimmunity. We therefore determined whether anti-neuronal or anti-glial autoantibodies are present in eleven consecutive severely ill COVID-19 patients presenting with unexplained neurological symptoms. These included myoclonus, cranial nerve involvement, oculomotor disturbance, delirium, dystonia and epileptic seizures. Most patients showed signs of CSF inflammation and increased levels of neurofilament light chain. All patients had anti-neuronal autoantibodies in serum or CSF when assessing a large panel of autoantibodies against intracellular and surface antigens relevant for central nervous system diseases using cell-based assays and indirect immunofluorescence on murine brain sections. Antigens included proteins well-established in clinical routine, such as Yo or NMDA receptor, but also a variety of specific undetermined epitopes on brain sections. These included vessel endothelium, astrocytic proteins and neuropil of basal ganglia, hippocampus or olfactory bulb. The high frequency of autoantibodies targeting the brain in the absence of other explanations suggests a causal relationship to clinical symptoms, in particular to hyperexcitability (myoclonus, seizures). While several underlying autoantigens still await identification in future studies, presence of autoantibodies may explain some aspects of multi-organ disease in COVID-19 and can guide immunotherapy in selected cases.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1101/2020.07.01.20143214
has license	medrxiv
sha1sum (hex)	e3f764a75fd0e5d6d586a55e32de22b459a63c19
schema:url	https://doi.org/10.1101/2020.07.01.20143214
resource representing a document's title	High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms
resource representing a document's body	covid:e3f764a75fd0e5d6d586a55e32de22b459a63c19#body_text
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