About: Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease

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About: Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease
Creator	Wang, Wei Wang, Jingjing Jin, Yu Yang, Guang Chen, Xiaoqing Li, Erguang Yang, Ziying Zhang, Yating Yang, G Ge, Hui
Source	Elsevier; Medline; PMC
abstract	Abstract Ethnopharmacological relevance The radices of Glycyrrhiza uralensis Fisch. and herbal preparations containing Glycyrrhiza spp. have been used for thousands of years as an herbal medicine for the treatment of viral induced cough, viral hepatitis, and viral skin diseases like ulcers in China. Glycyrrhizic acid (GA) is considered the principal component in Glycyrrhiza spp. with a wide spectrum of antiviral activity. Aim The present study attempt to validate the medicinal use of Glycyrrhiza uralensis for hand, foot and mouth disease (HFMD) and further to verify whether GA is an active antiviral component in the water extract of Glycyrrhiza uralensis. Materials and methods Radices of Glycyrrhiza uralensis Fisch. were extracted with hot water. The chemical contents of the extract were profiled with HPLC analysis. The antiviral activity of the extract and the major components was evaluated against infection of enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) on Vero cells. The cytopathic effect caused by the infection was measured with MTT assay. Infectious virion production was determined using secondary infection assays and viral protein expression by immunoblotting analysis. Results The extract at 1000μg/ml suppressed EV71 replication by 1.0 log and CVA16 by 1.5 logs. The antiviral activity was associated with the content of GA in the extract since selective depletion of GA from the extract by acid precipitation resulted in loss of antiviral activity. In contrast, the acid precipitant retained antiviral activity. The precipitant at a concentration of 200μg/ml inhibited EV71 and CVA16 replication by 1.7 and 2.2 logs, respectively. Furthermore, GA dose-dependently blocked viral replication of EV71 and CVA16. At 3mM, GA reduced infectious CVA16 and EV71 production by 3.5 and 2.2 logs, respectively. At 5mM, CVA16 production was reduced by 6.0 logs and EV71 by 4.0 logs. Both EV71 and CVA16 are members of Enterovirus genus, time-of-drug addition studies however showed that GA directly inactivated CVA16, while GA anti-EV71 effect was associated with an event(s) post virus cell entry. Conclusions This study validated the medicinal usefulness of radices Glycyrrhiza uralensis against the etiological agents of HFMD. In addition to the identification of GA as the antiviral component of Glycyrrhiza uralensis against EV71 and CVA16 infection, this study also reveals that GA inhibits EV71 and CVA16 with distinct mechanisms.
has issue date	2013-05-02(xsd:dateTime)
bibo:doi	10.1016/j.jep.2013.02.017
bibo:pmid	23454684
has license	els-covid
sha1sum (hex)	e3bcb07631afa12bc098d945bb31db52e8469455
schema:url	https://doi.org/10.1016/j.jep.2013.02.017
resource representing a document's title	Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease
has PubMed Central identifier	PMC7125661
has PubMed identifier	23454684
schema:publication	Journal of Ethnopharmacology
resource representing a document's body	covid:e3bcb07631afa12bc098d945bb31db52e8469455#body_text
is schema:about of	named entity 'Fisch.' named entity 'skin diseases' named entity 'activity' named entity 'VIRAL HEPATITIS' named entity 'USING' named entity 'MEASURED' named entity 'METHODS' named entity 'HERBAL MEDICINE' named entity 'CONSIDERED' named entity 'HPLC' named entity 'PRODUCTION' named entity 'CHEMICAL' named entity 'VIRAL SKIN DISEASES' named entity 'TREATMENT' named entity 'RELEVANCE' named entity 'COMPONENTS' named entity 'PRINCIPAL COMPONENT' named entity 'RADICES' named entity 'THOUSANDS' named entity 'DETERMINED' named entity 'CONTENTS' named entity 'COMPONENT' named entity 'USED' named entity 'FISCH' named entity 'INDUCED' named entity 'COUGH' named entity 'INFECTIOUS' named entity 'VIRAL PROTEIN' named entity 'CONTAINING' named entity 'HAVE' named entity 'SPECTRUM' named entity 'CAUSED BY' named entity 'VERIFY' named entity 'VIRAL' named entity 'HOT WATER' named entity 'COXSACKIEVIRUS A16' named entity 'GLYCYRRHIZA URALENSIS' named entity 'LIKE' named entity 'VIRION' named entity 'WATER' named entity 'ANALYSIS' named entity 'HAND' named entity 'GLYCYRRHIZIC ACID' named entity 'YEARS' named entity 'VERO CELLS' named entity 'HERBAL PREPARATIONS' named entity 'SECONDARY INFECTION' named entity 'STUDY' named entity 'CHINA' named entity 'ANTIVIRAL ACTIVITY' named entity 'MAJOR' named entity 'EXTRACTED' named entity 'SPP' named entity 'ULCERS' named entity 'CYTOPATHIC EFFECT' named entity 'WIDE' named entity 'AIM' named entity 'EVALUATED' named entity 'PROTEIN EXPRESSION' named entity 'INFECTION' named entity 'FOOT AND MOUTH DISEASE' named entity 'IMMUNOBLOTTING' named entity 'EXTRACT' named entity 'ENTEROVIRUS 71' named entity 'GLYCYRRHIZA' named entity 'PRESENT' named entity 'ANTIVIRAL' named entity 'USE OF' named entity 'ACTIVE' named entity 'MATERIALS' named entity 'MTT ASSAY' named entity 'ATTEMPT'

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