About: Association between nonspecific interstitial pneumonia and presence of CD20+ B lymphocytes within pulmonary lymphoid follicles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between nonspecific interstitial pneumonia and presence of CD20+ B lymphocytes within pulmonary lymphoid follicles
Creator	Qin, Ling Xu, Wenbing Liu, Hongrui Peng, Min Qin, Mingwei Wang, Wenze Zheng, Wenjie Zhu, Yuanjue Shi, Juhong
Source	PMC
abstract	Nonspecific interstitial pneumonia (NSIP) is characterised by interstitial infiltration of lymphocytes and varying amounts of interstitial fibrosis. B cells have been suggested to contribute to the pathogenesis of NSIP. However, the relationship between B-lymphocyte and the clinical outcomes of NSIP was unclear. In this study, 50 patients with histopathologically confirmed NSIP from Peking Union Medical College Hospital between April 2003 to December 2012 were retrospectively analyzed. Using immunohistochemical analyses, CD20+ B cells were counted in the lymphoid follicles, perivascular, interstitial, and peribronchiolar regions of lung tissure. The CD20+ lymphocytes were mainly present in the lymphoid follicles. The number of follicular CD20+ lymphocytes was higher in the fibrosing than cellular NSIP pattern [255.08 (132.92–449.71) vs. 121.33 (63.54–282.88)/0.1 mm(2), p = 0.017]. After 1 year of therapy, the follicular CD20+ lymphocytes were significantly higher in patients whose forced vital capacity (FVC) worsened as compared to those who improved (p = 0.014). Additionally, follicular CD20+ lymphocytes were negatively correlated with the post-treatment percentage change in FVC (rho = −0.397, p = 0.004). However, follicular CD20+ lymphocytes were not correlated with survival. These results suggested that pulmonary follicular CD20+ lymphocytes were correlated with the fibrosing pattern of NSIP and predicted less clinical improvement after treatment.
has issue date	2017-12-05(xsd:dateTime)
bibo:doi	10.1038/s41598-017-17208-1
bibo:pmid	29208971
has license	cc-by
sha1sum (hex)	e3b748c735f2ba33e17ce4d92cfac9293b1c4866
schema:url	https://doi.org/10.1038/s41598-017-17208-1
resource representing a document's title	Association between nonspecific interstitial pneumonia and presence of CD20+ B lymphocytes within pulmonary lymphoid follicles
has PubMed Central identifier	PMC5717047
has PubMed identifier	29208971
schema:publication	Sci Rep
resource representing a document's body	covid:e3b748c735f2ba33e17ce4d92cfac9293b1c4866#body_text
is schema:about of	named entity 'MEDICAL COLLEGE' named entity 'LUNG' named entity 'PERIVASCULAR' named entity 'HOSPITAL' named entity 'HIGHER' named entity 'LYMPHOCYTES' named entity 'PATTERN' named entity 'cellular' named entity 'OPEN' named entity 'interstitial pneumonia' named entity 'LYMPHOID FOLLICLES' named entity 'LYMPHOID FOLLICLES' named entity 'FOLLICULAR' named entity '282' named entity '1 MM' named entity 'USING' named entity '28132' named entity 'NUMBER OF' named entity 'CELLULAR' named entity 'PRESENCE OF' named entity 'B LYMPHOCYTES' named entity 'ASSOCIATION' named entity 'CD20' named entity 'PULMONARY' named entity 'OPEN' named entity 'NONSPECIFIC INTERSTITIAL PNEUMONIA' named entity 'NSIP' named entity 'IMMUNOHISTOCHEMICAL ANALYSES' named entity 'PRESENT' named entity 'REGIONS' named entity 'CD20' named entity 'DECEMBER' named entity 'ANALYZED' named entity 'APRIL' named entity 'INTERSTITIAL' named entity 'B CELLS' covid:arg/e3b748c735f2ba33e17ce4d92cfac9293b1c4866 named entity 'CD20' named entity '2003' named entity 'immunohistochemical' named entity 'lymphocytes' named entity 'Association' named entity 'Medical College Hospital' named entity 'fibrosing' named entity 'lung' named entity 'systemic sclerosis' named entity 'steroid' named entity 'pathogenesis' named entity 'parafollicular' named entity 'NSIP' named entity 'NSIP' named entity 'hypersensitivity pneumonitis' named entity 'air spaces' named entity 'ILDs' named entity 'NSIP' named entity 'CTD' named entity 'mice' named entity 'lymphocyte count' named entity 'follicular B cells' named entity 'fibrosing' named entity 'Hamamatsu Photonics' named entity 'antibody' named entity 'autoantibody' named entity 'serologically' named entity 'antibody test' named entity 'Chicago' named entity 'HRCT' named entity 'risk factor' named entity 'NSIP' named entity 'diagnostic criteria' named entity 'Peking Union Medical College Hospital' named entity 'lung inflammation' named entity 'autoantibody'

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