About: Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Acute Respiratory Distress Syndrome: A Prospective Observational Cohort Study

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About: Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Acute Respiratory Distress Syndrome: A Prospective Observational Cohort Study Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Acute Respiratory Distress Syndrome: A Prospective Observational Cohort Study
Creator	Yu, Chong-Jen Ho, Chao-Chi Ku, Shih-Chi Lin, Chih-An Lin, Ming-Tzer Wei, Yu-Feng
Source	Elsevier; Medline; PMC
abstract	Background/Purpose Serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), a detector of acute inflammatory response to microbial products and a good marker for diagnosing sepsis and pneumonia, has not yet been described as a predictor for infection or a prognostic factor in patients with acute respiratory distress syndrome (ARDS). Methods This prospective observational cohort study enrolled 63 ventilated adult patients with ARDS; 50 as septic and 13 as non-septic, and followed them for 28 days in intensive care units at a university hospital in Taiwan. Serial serum sTREM-1 levels and cytokines, such as interleukin (IL)-1, IL-8, and tumor necrosis factor-α, on days 1, 3, 5, 7 and 14 were measured by an enzyme-linked immunosorbent assay. The association between biomarkers and clinical infectious diagnosis/outcome in ARDS was explored. Results Serum sTREM-1 and cytokine levels could not differentiate septic from non-septic ARDS. Serum log sTREM-1 and inflammatory cytokine levels were correlated positively (r = 0.325 for IL-1β; r = 0.247 for IL-8; r = 0.480 for tumor necrosis factor-α). As prognostic factors, higher serum sTREM-1 level on day 1 and increasing levels over time, especially in the first 5 days, were independent predictors of mortality on day 28, using a multivariate Cox regression model. Serum sTREM-1 levels remained stable or even increased in the non-surviving patients, but decreased in the survivors. Conclusion Serum sTREM-1 level might not be a reliable marker for infection in ARDS patients. However, as an inflammatory marker, initial serum sTREM-1 level and its trend over time, especially in the first 5 days, could be predictive of short-term mortality. A progressive decline in serum sTREM-1 levels during follow-up indicates a favorable outcome, whereas persistently elevated sTREM-1 indicates a poor prognosis and should lead to a re-evaluation of therapy.
has issue date	2010-11-30(xsd:dateTime)
bibo:doi	10.1016/s0929-6646(10)60125-8
bibo:pmid	21126652
has license	els-covid
sha1sum (hex)	e38d4710ae273e9f1255994f9db03c8b408fdece
schema:url	https://doi.org/10.1016/s0929-6646%2810%2960125-8
resource representing a document's title	Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Acute Respiratory Distress Syndrome: A Prospective Observational Cohort Study
has PubMed Central identifier	PMC7138338
has PubMed identifier	21126652
schema:publication	Journal of the Formosan Medical Association
resource representing a document's body	covid:e38d4710ae273e9f1255994f9db03c8b408fdece#body_text
is schema:about of	named entity 'time' named entity 'multivariate' named entity 'good' named entity 'stable' named entity 'PROSPECTIVE OBSERVATIONAL COHORT' named entity 'PREDICTIVE' named entity 'ADULT' named entity 'POOR PROGNOSIS' named entity 'DIFFERENTIATE' named entity 'TAIWAN' named entity 'RE-EVALUATION' named entity 'INCREASING' named entity 'RESPONSE TO' named entity 'COHORT STUDY' named entity 'INTENSIVE CARE UNITS' named entity 'ELEVATED' named entity 'ACUTE INFLAMMATORY RESPONSE' named entity 'SURVIVORS' named entity 'TIME' named entity 'PERSISTENTLY' named entity 'CONCLUSION' named entity 'UNIVERSITY HOSPITAL' named entity 'SERIAL' named entity 'RESULTS' named entity 'VENTILATED' named entity 'DAY' named entity 'SOLUBLE' named entity 'LOG' named entity 'NON-' named entity 'SHORT-TERM' named entity 'INCREASED' named entity 'THERAPY' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1' named entity 'DIAGNOSIS' named entity 'IL-1' named entity 'FAVORABLE' named entity 'PNEUMONIA' named entity 'TUMOR NECROSIS FACTOR' named entity 'INTERLEUKIN ' named entity 'SEPTIC ARDS' named entity 'LEVELS' named entity 'HIGHER' named entity 'MORTALITY' named entity 'PROGRESSIVE DECLINE' named entity 'RELIABLE' named entity 'INFLAMMATORY MARKER' named entity '1 LEVEL' named entity '325' named entity 'METHODS' named entity 'TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1' named entity 'BACKGROUND' named entity '480' named entity 'PROGNOSTIC FACTORS' named entity 'DAYS' named entity 'COX REGRESSION MODEL' named entity 'ENROLLED' named entity 'SERUM' named entity 'PROSPECTIVE OBSERVATIONAL COHORT' named entity 'OUTCOME' named entity 'CLINICAL' named entity 'COHORT STUDY' named entity 'SEPSIS' named entity 'INFECTIOUS' named entity 'GOOD' named entity 'DIAGNOSING' named entity 'CORRELATED' named entity 'IL-8' named entity 'MICROBIAL' named entity 'ASSOCIATION' named entity 'MEASURED' named entity 'TREND' named entity 'PATIENTS' named entity 'INITIAL' named entity 'SEPTIC' named entity 'DETECTOR'

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