About: The Y chromosome: a blueprint for men’s health?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Y chromosome: a blueprint for men’s health?
Creator	Akbarov, Artur Charchar, Fadi Eales, James Jobling, Mark Maan, Akhlaq Rowland, Joshua Tomaszewski, Maciej Xu, Xiaoguang
Source	PMC
abstract	The Y chromosome has long been considered a ‘genetic wasteland’ on a trajectory to completely disappear from the human genome. The perception of its physiological function was restricted to sex determination and spermatogenesis. These views have been challenged in recent times with the identification of multiple ubiquitously expressed Y-chromosome genes and the discovery of several unexpected associations between the Y chromosome, immune system and complex polygenic traits. The collected evidence suggests that the Y chromosome influences immune and inflammatory responses in men, translating into genetically programmed susceptibility to diseases with a strong immune component. Phylogenetic studies reveal that carriers of a common European lineage of the Y chromosome (haplogroup I) possess increased risk of coronary artery disease. This occurs amidst upregulation of inflammation and suppression of adaptive immunity in this Y lineage, as well as inferior outcomes in human immunodeficiency virus infection. From structural analysis and experimental data, the UTY (Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked) gene is emerging as a promising candidate underlying the associations between Y-chromosome variants and the immunity-driven susceptibility to complex disease. This review synthesises the recent structural, experimental and clinical insights into the human Y chromosome in the context of men’s susceptibility to disease (with a particular emphasis on cardiovascular disease) and provides an overview of the paradigm shift in the perception of the Y chromosome.
has issue date	2017-08-30(xsd:dateTime)
bibo:doi	10.1038/ejhg.2017.128
bibo:pmid	28853720
has license	cc-by
sha1sum (hex)	e35ddb3ec39a3ee964c40b28e86e7960f265a26a
schema:url	https://doi.org/10.1038/ejhg.2017.128
resource representing a document's title	The Y chromosome: a blueprint for men’s health?
has PubMed Central identifier	PMC5643963
has PubMed identifier	28853720
schema:publication	Eur J Hum Genet
resource representing a document's body	covid:e35ddb3ec39a3ee964c40b28e86e7960f265a26a#body_text
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