About: Serum lipid profile changes and their clinical diagnostic significance in COVID-19 Mexican Patients

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About: Serum lipid profile changes and their clinical diagnostic significance in COVID-19 Mexican Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serum lipid profile changes and their clinical diagnostic significance in COVID-19 Mexican Patients
Creator	Aldama, " Antonio Ochoa-Ramírez, Luis Barajas-Martínez, Héctor Culiacan, De Jesús-González, Luis Farfan-Morales, Carlos Gastélum, Bernardo María Del Ángel, Rosa Montserrat Espinoza-Ortega, Arely Osuna-Ramos, Juan Ponce-Ramos, Héctor Rendón-Aguilar, Horacio Reyes-Ruiz, José Rodríguez-Millán, José Romero-Quintana, Geovanni Romero-Utrilla, Alejandra Ríos-Burgueño, Efrén Ríos-Tostado, Juan Salvador Velarde-Félix, Jesús Sinaloa, Mexico Soto-Almaral, Alejandro
source	MedRxiv
abstract	Background: COVID-19 has been recognized as an emerging and rapidly evolving health condition. For this reason, efforts to determine changes in laboratory parameters of COVID-19 patients as biomarkers are urgent. Lipids are essential components of the human body, and their modulation has been observed implicated in some viral infections. Methods: To evaluate the clinical diagnosis utility of the lipid profile changes in Mexican COVID-19 patients, the lipid profile of one hundred two COVID-19 positive patients from three hospitals in Culiacan, Sinaloa in northwest Mexico, was analyzed. ROC curves and binary logistic regression analysis were used as a predictive model to determine their clinical diagnostic utility. Results: Significant changes in the serum lipid profile of patients with COVID-19, such as low levels of cholesterol, LDL, and HDL, while high triglycerides and VLDL were observed. The same abnormalities in the lipid profile among non-critical and critical COVID-19 patients were detected. The predictive model analysis suggests that cholesterol and LDL have AUC values of 0.710 and 0.769, respectively, for COVID-19 (p= 0.0002 and p= <0.0001), and LDL low levels might be a risk factor for critical COVID-19 (OR= 2.07, 95% IC: 1.18 to 3.63; p= 0.01). Conclusion: Our findings suggest that low cholesterol and LDL levels could be considered an acceptable predictor for COVID-19, and low levels of LDL might be a risk factor for critical COVID-19 patients.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1101/2020.08.24.20169789
has license	medrxiv
sha1sum (hex)	e32e480d2a068d736ef47f5bc901731cc1ac0f3c
schema:url	https://doi.org/10.1101/2020.08.24.20169789
resource representing a document's title	Serum lipid profile changes and their clinical diagnostic significance in COVID-19 Mexican Patients
resource representing a document's body	covid:e32e480d2a068d736ef47f5bc901731cc1ac0f3c#body_text
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