About: Effect of 13 week magnetic field exposures on DMBA-initiated mammary gland carcinomas in female Sprague

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About: Effect of 13 week magnetic field exposures on DMBA-initiated mammary gland carcinomas in female Sprague–Dawley rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of 13 week magnetic field exposures on DMBA-initiated mammary gland carcinomas in female Sprague–Dawley rats
Creator	Anderson, Larry Morris, James Boorman, Gary Grumbein, Sondra Hailey, James Haseman, Joseph Mann, Peter Sasser, Lyle Sills, Robert Mcnally, Alan
Source	Medline; PMC
abstract	Several studies suggest that exposure to 50 Hz magnetic fields may promote chemically induced breast cancer in rats. Groups of 100 female Sprague–Dawley rats were initiated with four weekly 5 mg gavage doses of 7,12-dimethylbenz[a]anthracene (DMBA) starting at 50 days of age. After the first weekly DMBA administration, exposure to ambient fields (sham exposed), 50 Hz magnetic fields at either 1 or 5 G field intensity or 60 Hz fields at 1 G for 18.5 h/day, 7 days/week was initiated. Exposure continued for 13 weeks. A vehicle control group without DMBA was included. In a second study, using lower doses of DMBA, groups of 100 female Sprague–Dawley rats were initiated with four weekly doses of 2 mg of DMBA starting at 50 days of age followed, after the first weekly DMBA administration, by exposure to ambient fields (sham exposed) or 50 Hz magnetic fields at either 1 or 5 G field intensity for 18.5 h/day, 7 days/week for 13 weeks. Rats were weighed and palpated weekly for the presence of tumors. There was no effect of magnetic field exposure on body weight gains or on the time of appearance of mammary tumors in either study. At the end of 13 weeks, the animals were killed and the mammary tumors counted and measured. Mammary gland masses found grossly were examined histologically. In the first 13 week study, the mammary gland carcinoma incidences were 92, 86, 96 and 96% for the DMBA controls, 1 G, 50 Hz, 5 G, 50 Hz and 1 G, 60 Hz groups, respectively. The total numbers of carcinomas were 691, 528 (P < 0.05, decrease), 561 and 692 for the DMBA controls, 1 G, 50 Hz, 5 G, 50 Hz and 1 G, 60 Hz groups, respectively. In study 2, the mammary gland carcinoma incidences were 43, 48 and 38% for the DMBA controls, 1 G, 50 Hz and 5 G, 50 Hz groups, respectively. The total numbers of carcinomas were 102, 90 and 79 for the DMBA controls, 1 G, 50 Hz and 5 G, 50 Hz groups, respectively. There was no effect of magnetic field exposure on tumor size either by in-life palpation or by measurement at necropsy in either study. There was no evidence that 50 or 60 Hz magnetic fields promoted breast cancer in these studies in female rats. These studies do not support the hypothesis that magnetic field exposure promotes breast cancer in this DMBA rat model.
has issue date	1999-08-01(xsd:dateTime)
bibo:doi	10.1093/carcin/20.8.1615
bibo:pmid	10426815
has license	no-cc
sha1sum (hex)	e2bfc0831f73a484de738cd02f8dc3e14a705bf3
schema:url	https://doi.org/10.1093/carcin/20.8.1615
resource representing a document's title	Effect of 13 week magnetic field exposures on DMBA-initiated mammary gland carcinomas in female Sprague–Dawley rats
has PubMed Central identifier	PMC7185195
has PubMed identifier	10426815
schema:publication	Carcinogenesis
resource representing a document's body	covid:e2bfc0831f73a484de738cd02f8dc3e14a705bf3#body_text
is schema:about of	named entity 'study' named entity 'studies' named entity 'age' named entity 'rats' named entity 'study' named entity 'Groups' named entity 'tumor' named entity 'promoted' named entity 'mammary gland' named entity 'masses' named entity 'gains' named entity 'After' named entity 'body weight' named entity 'promotes' named entity 'Exposure' named entity 'control group' named entity 'study' named entity 'anthracene' named entity 'weekly' named entity 'doses' named entity 'size' named entity 'field intensity' named entity 'mammary gland' named entity 'groups' named entity 'carcinomas' named entity 'female' named entity '18.5' named entity 'magnetic fields' named entity 'tumor size' named entity 'palpated' named entity 'necropsy' named entity 'histologically' named entity 'tumors' named entity 'carcinomas' named entity 'carcinomas' named entity 'DMBA' named entity 'mammary gland' named entity 'carcinomas' named entity 'magnetic field' named entity 'days' named entity 'virus' named entity 'plastic' named entity 'tumors' named entity 'Hannover' named entity 'DMBA' named entity 'DMBA' named entity 'metastatic' named entity 'kidney' named entity 'Sprague-Dawley' named entity 'DMBA' named entity 'tumors' named entity 'tumors' named entity 'magnetic fields' named entity '2.0' named entity 'NIH' named entity 'Sprague-Dawley' named entity 'magnetic field' named entity 'DMBA' named entity 'liver' named entity 'DMBA' named entity 'gavage' named entity 'necropsy' named entity 'rat' named entity 'magnetic field' named entity 'breast cancer' named entity 'virus' named entity 'sesame oil' named entity 'DMBA' named entity 'DMBA' named entity 'control group' named entity 'electric fields' named entity '2.2'

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