About: SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings

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About: SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings
Creator	Britton, Philip Mcmullan, Brendan Bartlett, Adam Gray, Paul Howard-Jones, Annaleise Hsu, Peter Palasanthiran, Pamela Williams, Phoebe
Source	Elsevier; PMC
abstract	As the SARS-CoV-2 pandemic unfolds across the globe, consistent themes are emerging with regard to aspects of SARS-CoV-2 infection and its associated disease entities in children. Overall, children appear to be less frequently infected by, and affected by, SARS-CoV-2 virus and the clinical disease COVID-19. Large epidemiological studies have revealed children represent less than 2% of the total confirmed COVID-19 cases, of whom the majority experience minimal or mild disease that do not require hospitalisation. Children do not appear to be major drivers of SARS-CoV-2 transmission, with minimal secondary virus transmission demonstrated within families, schools and community settings. There are several postulated theories regarding the relatively low SARS-CoV-2 morbidity and mortality seen in children, which largely relate to differences in immune responses compared to adults, as well as differences in angiotensin converting enzyme 2 distribution that potentially limits viral entry and subsequent inflammation, hypoxia and tissue injury. The recent emergence of a multisystem inflammatory syndrome bearing temporal and serological plausibility for an immune-mediated SARS-CoV-2-related disease entity is currently under investigation. This article summarises the current available data regarding SARS-CoV-2 and the paediatric population, including the spectrum of disease in children, the role of children in virus transmission, and host-virus factors that underpin the unique aspects of SARS-CoV-2 pathogenicity in children.
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1016/j.pathol.2020.08.001
has license	no-cc
sha1sum (hex)	e285b3d7c8c391f9aecf74c1e63def142b357957
schema:url	https://doi.org/10.1016/j.pathol.2020.08.001
resource representing a document's title	SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings
has PubMed Central identifier	PMC7437539
schema:publication	Pathology
resource representing a document's body	covid:e285b3d7c8c391f9aecf74c1e63def142b357957#body_text
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