About: Evaluation of the Inhibitory Effects of (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one (DiNap), a Natural Product Analog, on the Replication of Type 2 PRRSV In Vitro and In Vivo

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About: Evaluation of the Inhibitory Effects of (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one (DiNap), a Natural Product Analog, on the Replication of Type 2 PRRSV In Vitro and In Vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of the Inhibitory Effects of (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one (DiNap), a Natural Product Analog, on the Replication of Type 2 PRRSV In Vitro and In Vivo
Creator	Khatun, Amina Kim, Won-Il Shabir, Nadeem Park, Sun Kim, Bumseok Seo, Byoung-Joo Jeong, Chang-Gi Kang, A-Rum Nazki, Salik Yang, Myeon-Sik Seo, Young Duval, E
Source	PMC
abstract	DiNap [(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one], an analog of a natural product (the chalcone flavokawain), was synthesized and characterized in this study. Porcine reproductive and respiratory syndrome virus (PRRSV) is the most challenging threat to the swine industry worldwide. Currently, commercially available vaccines are ineffective for controlling porcine reproductive and respiratory syndrome (PRRS) in pigs. Therefore, a pharmacological intervention may represent an alternative control measure for PRRSV infection. Hence, the present study evaluated the effects of DiNap on the replication of VR2332 (a prototype strain of type 2 PRRSV). Initially, in vitro antiviral assays against VR2332 were performed in MARC-145 cells and porcine alveolar macrophages (PAMs). Following this, a pilot study was conducted in a pig model to demonstrate the effects of DiNap following VR2332 infection. DiNap inhibited VR2332 replication in both cell lines in a dose-dependent manner, and viral growth was completely suppressed at concentrations ≥0.06 mM, without significant cytotoxicity. Consistent with these findings, in the pig study, DiNap also reduced viral loads in the serum and lungs and enhanced the weight gain of pigs following VR2332 infection, as indicated by comparison of the DiNap-treated groups to the untreated control (NC) group. In addition, DiNap-treated pigs had fewer gross and microscopic lesions in their lungs than NC pigs. Notably, virus transmission was also delayed by approximately 1 week in uninfected contact pigs within the same group after treatment with DiNap. Taken together, these results suggest that DiNap has potential anti-PRRSV activity and could be useful as a prophylactic or post-exposure treatment drug to control PRRSV infection in pigs.
has issue date	2019-03-03(xsd:dateTime)
bibo:doi	10.3390/molecules24050887
bibo:pmid	30832429
has license	cc-by
sha1sum (hex)	e283c964691d950836fd62790ff4c032b8b1a56a
schema:url	https://doi.org/10.3390/molecules24050887
resource representing a document's title	Evaluation of the Inhibitory Effects of (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one (DiNap), a Natural Product Analog, on the Replication of Type 2 PRRSV In Vitro and In Vivo
has PubMed Central identifier	PMC6429065
has PubMed identifier	30832429
schema:publication	Molecules
resource representing a document's body	covid:e283c964691d950836fd62790ff4c032b8b1a56a#body_text
is schema:about of	named entity 'MOLECULES' named entity 'pig' named entity 'effects' named entity 'delayed' named entity 'conducted' named entity 'groups' named entity 'porcine' named entity 'chalcone' named entity 'study' named entity 'evaluated' named entity 'performed' named entity 'analog' named entity 'Vivo' named entity 'EN-1' named entity 'EVALUATION' named entity 'A50' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME' named entity 'PROPHYLACTIC' named entity 'PILOT STUDY ' named entity 'THESE' named entity 'INFECTION' named entity 'NATURAL PRODUCT' named entity 'ANALOG' named entity 'CURRENTLY' named entity 'FOLLOWING' named entity 'INEFFECTIVE' named entity 'EN-1' named entity 'DRUG' named entity 'VIRAL' named entity 'SYNTHESIZED' named entity 'UNTREATED' named entity 'DELAYED' named entity 'UNINFECTED' named entity 'VACCINES' named entity 'ALTERNATIVE' named entity 'MARC' named entity 'EFFECTS' named entity 'TRANSMISSION' named entity 'SERUM' named entity 'CYTOTOXICITY' named entity 'POTENTIAL' named entity 'STUDY' named entity 'MEASURE' named entity 'MICROSCOPIC' named entity 'LESIONS' named entity 'REPLICATION' named entity 'IN VITRO' named entity 'GROUPS' named entity 'PRESENT' named entity 'TO CONTROL' named entity 'COULD BE' named entity 'MODEL' named entity 'INHIBITORY' named entity '282' named entity 'HYDROXY' named entity 'EFFECTS' named entity 'PRRSV' named entity 'IN VITRO' named entity 'POST' named entity 'SWINE' named entity 'ACTIVITY' named entity 'PIG' named entity 'CELL LINES' named entity 'ENHANCED' named entity 'USEFUL' named entity 'COMPLETELY' named entity 'INHIBITED' named entity 'CELLS' named entity 'CONTROL'

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