About: Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia

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About: Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
Creator	Navarro, David Giménez, Estela Solano, Carlos Amat, Paula Balaguer-Roselló, Aitana Carretero, Carlos Moles, Paula Montoro, Juan Pérez, Ariadna Salavert, Miguel Sanz, Guillermo Sanz, Jaime Vinuesa, Víctor Carlos Hernández-Boluda, Juan Dolores Gómez, María Luis Piñana, José María González, Eva
topic	covid:e280d408d6d8301a7f280d72f84cf9e9d2db8240#this
source	Elsevier; Medline; PMC
abstract	Summary Objectives To date no definitive cut-off value for cytomegalovirus (CMV) DNA load in bronchoalveolar lavage (BAL) fluid specimens has been established to discriminate between CMV pneumonia and pulmonary CMV DNA shedding in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. Methods The current retrospective study is aimed at assessing the range of CMV DNA loads quantified in BAL fluid specimens from allo-HSCT patients with pneumonia in which different microorganisms were causally involved. Results A total of 144 BAL specimens from 123 patients were included. CMV DNA was detected in 56 out of 144 BAL fluid specimens and the median CMV DNA load from patients in whom CMV pneumonia was unlikely or could be tentatively ruled out was 1210 (31–68, 920) IU/ml. The frequency of CMV DNA detection and median CMV DNA loads were comparable, irrespective of the attributable cause of pneumonia. Detection of CMV DNA loads in BAL fluid specimens >500 IU/ml was independently associated with pneumonia-attributable mortality. Conclusions The current study highlights the difficulty in establishing universal CMV DNA load thresholds in BAL fluid specimens for distinguishing between CMV pneumonia and pulmonary CMV DNA shedding, and suggests that the presence of CMV DNA in BAL fluid specimens beyond a certain level may have a deleterious impact on patient outcome.
has issue date	2019-05-31(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2019.02.009
bibo:pmid	30797790
has license	els-covid
sha1sum (hex)	e280d408d6d8301a7f280d72f84cf9e9d2db8240
schema:url	https://doi.org/10.1016/j.jinf.2019.02.009
resource representing a document's title	Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
has PubMed Central identifier	PMC7126576
has PubMed identifier	30797790
schema:publication	Journal of Infection
resource representing a document's body	covid:e280d408d6d8301a7f280d72f84cf9e9d2db8240#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e280d408d6d8301a7f280d72f84cf9e9d2db8240
is schema:about of	named entity 'CMV PNEUMONIA' named entity 'specimens' named entity 'quantified' named entity 'specimens' named entity 'pneumonia' named entity 'HEMATOPOIETIC STEM CELL' named entity 'CYTOMEGALOVIRUS' named entity '920' named entity 'ALLOGENEIC' named entity 'DIFFERENT' named entity 'RESULTS' named entity 'IMPACT' named entity 'DATE' named entity 'RULED OUT' named entity 'CURRENT' named entity 'METHODS' named entity 'DISTINGUISHING' named entity 'CYTOMEGALOVIRUS' named entity 'PNEUMONIA' named entity 'HEMATOPOIETIC STEM CELL' named entity 'ALLOGENEIC' named entity 'DNA' named entity 'HSCT' named entity 'COULD BE' named entity 'DNA' named entity 'UNLIKELY' named entity 'OBJECTIVES' named entity 'PULMONARY' named entity 'RETROSPECTIVE STUDY' named entity 'DEFINITIVE' named entity 'MEDIAN' named entity 'TRANSPLANT RECIPIENTS' named entity 'DIFFICULTY' named entity 'LEVEL' named entity 'DETECTED' named entity 'SHEDDING' named entity 'DIAGNOSIS' named entity 'PULMONARY' named entity 'FLUID' named entity 'ATTRIBUTABLE' named entity 'RANGE' named entity 'STEM CELL TRANSPLANT' named entity 'CONCLUSIONS' named entity 'STEM CELL TRANSPLANT' named entity 'CMV DNA' named entity 'SPECIMENS' named entity '500' named entity 'DETECTION' named entity 'LOAD' named entity 'ESTABLISHED' named entity 'ASSESSING' named entity 'PATIENTS' named entity 'SHEDDING' named entity 'UNIVERSAL' named entity 'DISCRIMINATE' named entity 'CMV PNEUMONIA' named entity 'STUDY' named entity 'MICROORGANISMS' named entity 'INVOLVED' named entity 'TOTAL' named entity 'INCLUDED' named entity 'BRONCHOALVEOLAR LAVAGE' named entity 'CUT-OFF VALUE'

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