About: Rituximab-Related Pulmonary Toxicity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rituximab-Related Pulmonary Toxicity
Creator	Herishanu, Y Herishanu, Yair Perry, C Perry, Chava Polliack, Aaron Polliack, A
Source	PMC
abstract	We report the case of an 80-year-old man treated for follicular grade 3B non-Hodgkin’s lymphoma (NHL). Immunochemotherapy consisted of rituximab (375 mg/m(2)) and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) every 21 days. Since the patient complained of mild dyspnea on effort with bilateral basilar crackles audible on auscultation, PET-CT was performed and showed disappearance of the initial 18F-FDG uptake, but new abnormal sites of 18F-FDG uptake were evident in the sub-pleural areas of the lung, mostly on the right side. After starting the fifth cycle of rituximab-CHOP, the dyspnea worsened. Chest-X ray and HRCT were consistent with an interstitial infiltration, including sub-pleural air-space consolidation, and “ground-glass” opacities, small pulmonary cysts and thickening of the interlobular septa were also seen. Trans-bronchial biopsy was performed and revealed interstitial inflammation of the lung parenchyma, as well as swelling and hyperplasia of atypical type II alveolar cells. Alternative diagnoses than drug-related pulmonary toxicity are discussed, and a literature review is provided.
has issue date	2010-08-19(xsd:dateTime)
bibo:doi	10.1007/978-3-642-15742-4_64
has license	no-cc
sha1sum (hex)	e26a7c2370b226a2ee41a61c9cfb9b68317c322e
schema:url	https://doi.org/10.1007/978-3-642-15742-4_64
resource representing a document's title	Rituximab-Related Pulmonary Toxicity
has PubMed Central identifier	PMC7123637
schema:publication	Pulmonary Involvement in Patients with Hematological Malignancies
resource representing a document's body	covid:e26a7c2370b226a2ee41a61c9cfb9b68317c322e#body_text
is schema:about of	named entity 'diaphragm' named entity 'side' named entity 'lung' named entity 'follicular' named entity 'combination' named entity 'growing' named entity 'patient' named entity 'abnormal' named entity 'scan' named entity 'imaging' named entity 'man' named entity 'treated' named entity 'positron emission tomography-computed tomography' named entity 'mandibular' named entity 'Pulmonary Toxicity' named entity 'lung' named entity 'reactive oxygen' named entity 'PET-CT' named entity 'CLL' named entity 'mechanical ventilation' named entity 'ITP' named entity 'CD20' named entity 'influenza' named entity 'intravenous' named entity 'lung' named entity 'diffuse alveolar hemorrhage' named entity 'fludarabine' named entity 'hemorrhages' named entity 'B-cell' named entity 'lung tissue' named entity 'antibody' named entity 'lung' named entity 'urine' named entity 'CT scan' named entity 'rituximab' named entity 'vacuoles' named entity 'dry cough' named entity 'international prognostic index' named entity 'hyperplasia' named entity 'lymphadenopathy' named entity 'IL-6' named entity 'lymphoma' named entity 'infection' named entity 'inflammation' named entity 'TNF antagonist' named entity 'CD4+' named entity 'lung biopsy' named entity 'lung' named entity 'lung' named entity 'chronic lymphocytic leukemia' named entity 'pulmonary toxicity' named entity 'CMV' named entity 'dyspnea' named entity 'Crackles' named entity 'infection' named entity 'malignant cells' named entity 'T-lymphocytes' named entity 'CT scan' named entity 'pulmonary toxicity' named entity 'chemotherapy' named entity 'fever' named entity 'pulmonary toxicity' named entity 'cytokine release syndrome' named entity 'toxicity' named entity 'cysts' named entity 'diffusion capacity' named entity 'neutropenia' named entity 'autoimmune disorders' named entity 'European Medicines Agency' named entity 'NHL' named entity 'malignant cells' named entity 'dyspnea' named entity 'chest CT scan' named entity 'cytotoxic T-cell' named entity 'hyperchromasia' named entity 'cytomegalovirus' named entity 'rituximab' named entity 'chronic lung disease'

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