About: Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools
Creator	Cheng, Yuanxiong Fu, Yajing Wu, Yuntao
Source	Medline; PMC
abstract	Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various mechanisms of SARS-CoV-mediated inflammation. We also assume that SARS-CoV-2 likely shares similar inflammatory responses. Potential therapeutic tools to reduce SARS-CoV-2-induced inflammatory responses include various methods to block FcR activation. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. However, these strategies, as proposed here, remain to be clinically tested for effectiveness.
has issue date	2020-03-03(xsd:dateTime)
bibo:doi	10.1007/s12250-020-00207-4
bibo:pmid	32125642
has license	no-cc
sha1sum (hex)	e264af5a579218b8fb75b0848c49f2adc57c6bc5
schema:url	https://doi.org/10.1007/s12250-020-00207-4
resource representing a document's title	Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools
has PubMed Central identifier	PMC7090474
has PubMed identifier	32125642
schema:publication	Virol Sin
resource representing a document's body	covid:e264af5a579218b8fb75b0848c49f2adc57c6bc5#body_text
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