About: Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor

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About: Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor
Creator	Lee, Chang-Seop Kim, Seong-Jun Jun, Sangmi Kim, Tae Kim, Hong Kim, Mi Kim, Seung Baek, Seung-Hwa Park, Daeui Changkyun Park, Edmond Choi, Minsuk Ku, Bon Lee, Geonhee Lee, Jeong-O Seo, Giwan
source	Medline; PMC
abstract	[Image: see text] Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously called 2019-nCoV). Based on the rapid increase in the rate of human infection, the World Health Organization (WHO) has classified the COVID-19 outbreak as a pandemic. Because no specific drugs or vaccines for COVID-19 are yet available, early diagnosis and management are crucial for containing the outbreak. Here, we report a field-effect transistor (FET)-based biosensing device for detecting SARS-CoV-2 in clinical samples. The sensor was produced by coating graphene sheets of the FET with a specific antibody against SARS-CoV-2 spike protein. The performance of the sensor was determined using antigen protein, cultured virus, and nasopharyngeal swab specimens from COVID-19 patients. Our FET device could detect the SARS-CoV-2 spike protein at concentrations of 1 fg/mL in phosphate-buffered saline and 100 fg/mL clinical transport medium. In addition, the FET sensor successfully detected SARS-CoV-2 in culture medium (limit of detection [LOD]: 1.6 × 10(1) pfu/mL) and clinical samples (LOD: 2.42 × 10(2) copies/mL). Thus, we have successfully fabricated a promising FET biosensor for SARS-CoV-2; our device is a highly sensitive immunological diagnostic method for COVID-19 that requires no sample pretreatment or labeling.
has issue date	2020-04-15(xsd:dateTime)
bibo:doi	10.1021/acsnano.0c02823
bibo:pmid	32293168
has license	no-cc
sha1sum (hex)	e1d1d7457960c17f7a93cf8cf31dbb6c35f447aa
schema:url	https://doi.org/10.1021/acsnano.0c02823
resource representing a document's title	Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor
has PubMed Central identifier	PMC7172500
has PubMed identifier	32293168
schema:publication	ACS Nano
resource representing a document's body	covid:e1d1d7457960c17f7a93cf8cf31dbb6c35f447aa#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'detecting' named entity 'COVID-19' named entity 'human' named entity 'outbreak' named entity 'rapid' named entity 'Specimens' named entity 'Transistor' named entity 'produced' named entity 'Coronavirus disease 2019' named entity 'graphene' named entity 'field-effect transistor' named entity 'SARS-CoV-2' named entity 'infection' named entity 'classified' named entity 'Human' named entity 'FET' named entity 'COVID' named entity 'early diagnosis' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Virus' named entity 'World Health Organization' named entity 'N 2' named entity 'protein' named entity 'graphene' named entity 'antigen' named entity 'ACE2' named entity 'transmembrane protein' named entity 'SARS-CoV-2 virus' named entity 'COVID-19' named entity 'graphene' named entity 'HR-TEM' named entity 'SARS-CoV-2' named entity 'morphology' named entity 'transport medium' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'real-time RT-PCR' named entity 'PMMA' named entity 'Thermo Fisher Scientific' named entity 'COVID-19' named entity 'MERS-CoV' named entity 'antigen' named entity 'graphene' named entity 'Clinical samples' named entity 'clinical samples' named entity 'diagnostic methods' named entity 'nasopharyngeal swab' named entity 'COVID-19' named entity 'SARS-CoV' named entity 'antibody' named entity 'Thermo Fisher Scientific' named entity 'graphene' named entity 'antigen proteins' named entity 'asymptomatic' named entity 'China' named entity 'graphene' named entity 'PBS' named entity 'FET' named entity 'Jeonbuk National University' named entity 'graphene' named entity 'clinical samples' named entity 'SARS' named entity 'deionized (DI) water' named entity 'clinical samples' named entity 'Hubei province'

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