About: Hypocortisolism in survivors of severe acute respiratory syndrome (SARS)

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hypocortisolism in survivors of severe acute respiratory syndrome (SARS)
Creator	Lee, Lawrence Soon-U Ong, Kian-Chung Ng, Wei-Keong Khee, Melvin Kwek, Leow, Shing Gregory, Jon-Leng Kaw, Seow-Khee, Daniel
source	PMC
abstract	Objective Following the severe acute respiratory syndrome (SARS) outbreak, many survivors were observed to suffer from psychosomatic symptoms reminiscent of various endocrine disorders. Hence, we sought to determine the existence of any chronic endocrine sequelae in SARS survivors. Design, patients, measurements Sixty‐one survivors of SARS prospectively recruited were analysed for hormonal derangements 3 months following recovery. Patients with pre‐existing endocrine disorders were excluded. Any endocrine abnormalities diagnosed were investigated and treated where indicated up to a year. Serial evaluation facilitated characterization of trends and prognostication of any endocrinological aberrations. Results Twenty‐four (39·3%) patients had evidence of hypocortisolism. The hypothalamic–pituitary–adrenal (HPA) axis dysfunction of the majority resolved within a year. Two (3·3%) of the hypocortisolic cohort had transient subclinical thyrotoxicosis. Four (6·7%) were biochemically hypothyroid, being comprised of three with central hypothyroidism and one with primary hypothyroidism. Two of the three with central hypothyroidism had concomitant central hypocortisolism. Eight had subnormal DHEAS levels. Conclusions These preliminary findings highlight a possible aetiologic role of SARS‐associated coronavirus in causing a reversible hypophysitis or direct hypothalamic effect, with the HPA axis affected more frequently than the HPT axis.
has issue date	2005-07-05(xsd:dateTime)
bibo:doi	10.1111/j.1365-2265.2005.02325.x
has license	no-cc
sha1sum (hex)	e17181b8cb2bdd46261ea65500bc8ac913f646e2
schema:url	https://doi.org/10.1111/j.1365-2265.2005.02325.x
resource representing a document's title	Hypocortisolism in survivors of severe acute respiratory syndrome (SARS)
has PubMed Central identifier	PMC7188349
schema:publication	Clin Endocrinol (Oxf)
resource representing a document's body	covid:e17181b8cb2bdd46261ea65500bc8ac913f646e2#body_text
is schema:about of	named entity 'symptoms' named entity 'dysfunction' named entity 'endocrine' named entity 'CHARACTERIZATION' named entity 'YEAR' named entity 'PITUITARY' named entity 'PRIMARY HYPOTHYROIDISM' named entity 'THESE' named entity 'THYROTOXICOSIS' named entity 'PROGNOSTICATION' named entity 'HYPOTHYROID' named entity 'HYPOTHALAMIC' named entity 'FINDINGS' named entity 'PATIENTS' named entity 'INVESTIGATED' named entity '3 MONTHS' named entity 'INDICATED' named entity 'FREQUENTLY' named entity '283' named entity 'CONCLUSIONS' named entity 'SIXTY-ONE' named entity 'DETERMINE' named entity 'DHEAS' named entity 'Two' named entity 'hypothyroidism' named entity 'prognostication' named entity 'hypothyroidism' named entity 'suffer' named entity 'psychosomatic' named entity 'investigated' named entity 'evaluation' named entity 'hypocortisolism' named entity 'levels' named entity 'measurements' named entity 'patients' named entity 'hypocortisolism' named entity 'SARS' named entity 'endocrinological' named entity 'severe acute respiratory syndrome' named entity 'endocrine disorders' named entity 'hypothyroidism' named entity 'hypothalamic-pituitary-adrenal (HPA) axis' named entity 'HPT' named entity 'thyrotoxicosis' named entity 'aberrations' named entity 'autoantibodies' named entity 'extrapulmonary' named entity 'dehydroepiandrosterone' named entity 'SARS' named entity 'lipotropin' named entity 'subclinical' named entity 'adrenal' named entity 'DHEAS' named entity 'SARS' named entity 'psychosomatic' named entity 'immunoassay' named entity 'medical literature' named entity 'anorexia' named entity 'Chaska' named entity 'hypercalcaemia' named entity 'cortisol' named entity 'gene' named entity 'autoantibodies' named entity 'SARS-CoV' named entity 'pyrexia' named entity 'Institutional Review Board' named entity 'ACTH' named entity 'hypocortisolism' named entity 'hypothyroidism' named entity 'hypocortisolism' named entity 'sequelae' named entity 'thyroid' named entity 'dizziness' named entity 'apathy' named entity 'SST1'

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