About: The role of phagocytic cells in enhanced susceptibility of broilers to colibacillosis after Infectious Bronchitis Virus infection

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About: The role of phagocytic cells in enhanced susceptibility of broilers to colibacillosis after Infectious Bronchitis Virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of phagocytic cells in enhanced susceptibility of broilers to colibacillosis after Infectious Bronchitis Virus infection
Creator	Vervelde, Lonneke Ariaans, Mark Hensen, Evert Matthijs, Mieke Van De Haar, Peter Van Eck, Jo Van Haarlem, Daphne
topic	covid:e16106d6b08f7006c7fa7d713db19a0027e1d172#this
Source	Elsevier; Medline; PMC
abstract	Colibacillosis results from infection with avian pathogenic Escherichia coli bacteria. Healthy broilers are resistant to inhaled E. coli, but previous infection with vaccine or virulent strains of Infectious Bronchitis Virus (IBV) predisposes birds for severe colibacillosis. We investigated whether IBV affects recruitment and function of phagocytic cells and examined NO production, phagocytic and bactericidal activity, and kinetics of peripheral blood mononuclear cells (PBMC) and splenocytes. Moreover, we measured cytokine mRNA expression in lung and spleen samples. Broilers were inoculated with IBV H120 vaccine or virulent M41 and challenged 5 days later with E. coli 506. A PBS control and E. coli group without previous virus inoculation were also included. Birds were sacrificed at various time points after inoculation (h/dpi). Inoculation with IBV induced extended and more severe colibacillosis than with E. coli alone. At 4 dpi, the number of KUL-01(+) PBMC in all E. coli-inoculated groups was significantly higher than in PBS-inoculated birds, which correlated with lesion scores. From 1 to 4 dpi, NO production by PBMC from all E. coli-inoculated animals was elevated compared to PBS birds. Bactericidal activity of PBMC in IBV-inoculated animals at 7 dpi was lower than in PBS- and E. coli-inoculated birds, but phagocytic capacity and recruitment were not severely impaired. In spleen samples of IBV-infected animals reduced expression of IL-1β, IL-6, IL-8, IL-10, IL-18 and IFN-γ mRNA was found 1 dpi. Our results suggest that enhanced colibacillosis after IBV infection or vaccination is caused at least by altered innate immunity and less by impairment of phagocytic cell function.
has issue date	2008-06-15(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2008.02.003
bibo:pmid	18359518
has license	no-cc
sha1sum (hex)	e16106d6b08f7006c7fa7d713db19a0027e1d172
schema:url	https://doi.org/10.1016/j.vetimm.2008.02.003
resource representing a document's title	The role of phagocytic cells in enhanced susceptibility of broilers to colibacillosis after Infectious Bronchitis Virus infection
has PubMed Central identifier	PMC7112703
has PubMed identifier	18359518
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:e16106d6b08f7006c7fa7d713db19a0027e1d172#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e16106d6b08f7006c7fa7d713db19a0027e1d172
is schema:about of	named entity 'E. coli' named entity 'virus' named entity 'birds' named entity 'IBV' named entity 'colibacillosis' named entity 'dpi' named entity 'susceptibility' named entity 'Bronchitis' named entity 'IFN-G' named entity 'HIGHER' named entity 'COLIBACILLOSIS' named entity 'CAUSED' named entity 'MRNA' named entity 'M41' named entity 'FUNCTION' named entity 'TIME' named entity 'MEASURED' named entity 'VARIOUS' named entity 'INDUCED' named entity 'SPLENOCYTES' named entity 'IL-1B' named entity 'KUL' named entity 'POINTS' named entity 'IL-18' named entity 'EXTENDED' named entity 'IMPAIRED' named entity 'OUR' named entity 'EXAMINED' named entity 'CELLS' named entity 'BUT' named entity 'INFECTED' named entity 'INVESTIGATED' named entity 'PBS' named entity 'INNATE IMMUNITY' named entity 'GROUPS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'SUSCEPTIBILITY' named entity 'COLIBACILLOSIS' named entity 'ROLE' named entity 'VIRUS INFECTION' named entity 'ENHANCED' named entity 'MRNA EXPRESSION' named entity 'LOWER' named entity 'LESION' named entity 'INHALED' named entity 'RECRUITMENT' named entity 'INCLUDED' named entity 'IL-6' named entity 'LATER' named entity 'AVIAN' named entity 'INFECTION' named entity 'GROUP' named entity 'FOUND' named entity 'CYTOKINE ' named entity 'CONTROL' named entity 'CELL FUNCTION' named entity 'COMPARED' named entity 'BIRDS' named entity 'DPI' named entity 'STRAINS' named entity 'VIRULENT' named entity 'ENHANCED' named entity 'IMPAIRMENT' named entity 'CELLS' named entity 'IL-8' named entity 'NUMBER OF' named entity 'RESISTANT TO' named entity '10%' named entity 'PREVIOUS' named entity 'VIRUS' named entity 'EXPRESSION' named entity 'PHAGOCYTIC CELL' named entity 'PATHOGENIC'

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