About: TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis

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About: TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis
Creator	Ahmed, Ahmed Al-Dhubaibi, Mohammed Alzolibani, Abdullateef Rasheed, Zafar Robaee, Ahmad Salem, Tarek
Source	Medline; PMC
abstract	BACKGROUND: Cutaneous leishmaniasis (CL) is well linked with immunogenetic factors. This study was undertaken to test the association of TNF-α − 308 and IFN-γ + 874 gene polymorphisms with the susceptibility of Leishmania (L) species among CL patients in central region of Saudi Arabia. METHODS: This is a case-control study involved 169 Saudi subjects with different L. species and 199 healthy controls from central region of Saudi Arabia. All subjects were characterized by TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms using PCR. RESULTS: Evaluation of genotyping and allelic frequency of TNF-α − 308 G/A in different L. species showed no significant association compared to controls (p > 0.05). Except, in cases of L. tropica that showed significantly higher TNF-α − 308 A versus G allele frequency (p = 0.0004). Evaluation of genotyping of IFN-γ + 874 (TT versus AA+AT recessive) and allelic frequency of IFN-γ + 874 (T versus A) showed significant higher in L. major and also in total CL cases as compared to healthy controls (p < 0.05). Furthermore, a strong association was observed between the susceptibility of L. major, L. tropica or total CL cases with synergistically combined high TNF-α 308/INF-γ 874 alleles. CONCLUSIONS: This is the first report that shows the gene polymorphisms of TNF-α − 308 G/A and IFN-γ + 874 A/T in Saudi patients with different L. species infections. Data showed that the TNF-α-308 G/A gene polymorphism is not associated with the susceptibility of CL in Saudi subjects. The only correlation was found in between A versus G allelic frequency in L. tropica. Importantly, IFN-γ + 874 A/T polymorphism was found to be associated with the susceptibility of L. major and also with total CL subjects. Moreover, data from synergistically combined high TNF-α 308/INF-γ 874 alleles strongly suggest their potential role in the susceptibility of leishmania infection.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1186/s12881-020-01043-9
bibo:pmid	32404058
has license	cc-by
sha1sum (hex)	e114b20334e8e7508338a730d51490994b68ce3a
schema:url	https://doi.org/10.1186/s12881-020-01043-9
resource representing a document's title	TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis
has PubMed Central identifier	PMC7218653
has PubMed identifier	32404058
schema:publication	BMC Med Genet
resource representing a document's body	covid:e114b20334e8e7508338a730d51490994b68ce3a#body_text
is schema:about of	named entity 'Saudi Arabia' named entity 'leishmaniasis' named entity 'Leishmania' named entity 'TNF-α' named entity 'immunogenetic' named entity 'IFN-γ' named entity 'TNF-α' named entity 'polymorphisms' named entity 'polymorphism' named entity 'animal model' named entity 'TNFα' named entity 'TNF-α' named entity 'PCR' named entity 'polymorphisms' named entity 'pathogenesis' named entity 'Th1' named entity 'polymorphism' named entity 'cytokines' named entity 'PCR' named entity 'polymorphism' named entity 'PCR' named entity 'genomic DNA' named entity 'pathogenesis' named entity 'gene' named entity 'TNF-α' named entity 'genotype' named entity 'Iran' named entity 'infection' named entity 'tumor necrosis factor alpha' named entity 'denaturation' named entity 'phlebotomine sandflies' named entity 'UV light' named entity 'TNF-α' named entity 'IFN-γ' named entity 'transcriptional activity' named entity 'Th1' named entity 'homozygote' named entity 'proinflammatory cytokines' named entity 'TNF-α' named entity 'gene polymorphism' named entity 'allele' named entity 'INF-γ' named entity 'tissue damage' named entity 'parasites' named entity 'polymorphism' named entity 'genotypes' named entity 'infection' named entity 'lesion' named entity 'gene' named entity 'IFN-γ' named entity 'Th1' named entity 'genotype' named entity 'visceral leishmaniasis' named entity 'macrophages' named entity 'SPSS' named entity 'base pair' named entity 'L. tropica' named entity 'leishmania' named entity 'genotype' named entity 'IFN-γ' named entity 'cytokines' named entity 'INF-γ' named entity 'polymorphisms' named entity 'Saudi Arabia' named entity 'leishmaniasis' named entity 'infection' named entity 'endemic' named entity 'refractory' named entity 'IFN-γ' named entity 'Cutaneous leishmaniasis' named entity 'dermal' named entity 'gene' named entity 'polymorphisms' named entity 'genotypes' named entity 'protozoan' named entity 'L. tropica'

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