About: Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice
Creator	Botzman, Maya Gat-Viks, Irit Abu-Toamih, Hanifa Atamni, Correspondence, Fuad Fuad, \| Iraqi, Iraqi, A Mott, \| Safra, Edmond
Source	PMC
abstract	BACKGROUND: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology. METHODS: Liver weight of 506 mice generated from 39 different Collaborative Cross (CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high‐density single nucleotide polymorphic markers. RESULTS: Statistical analysis revealed a significant (P < 0.05) variation of liver weight between the CC lines, with broad sense heritability (H (2)) of 0.32 and genetic coefficient of variation (CV(G)) of 0.28. Subsequently, quantitative trait locus (QTL) mapping was performed, and results showed a significant QTL only for females on chromosome 8 at genomic interval 88.61‐93.38 Mb (4.77 Mb). Three suggestive QTL were mapped at chromosomes 4, 12 and 13. The four QTL were designated as LWL1‐LWL4 referring to liver weight loci 1‐4 on chromosomes 8, 4, 12 and 13, respectively. CONCLUSION: To our knowledge, this report presents, for the first time, the utilization of the CC for mapping QTL associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes.
has issue date	2018-10-24(xsd:dateTime)
bibo:doi	10.1002/ame2.12036
bibo:pmid	30891567
has license	cc-by
sha1sum (hex)	e0dbc66f68bc3baa8294c1fea46d8940f8a692db
schema:url	https://doi.org/10.1002/ame2.12036
resource representing a document's title	Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice
has PubMed Central identifier	PMC6388055
has PubMed identifier	30891567
schema:publication	Animal Model Exp Med
resource representing a document's body	covid:e0dbc66f68bc3baa8294c1fea46d8940f8a692db#body_text
is schema:about of	named entity 'COLLABORATIVE CROSS MICE' named entity 'LIVER WEIGHT' named entity 'GENETIC ARCHITECTURE' covid:arg/e0dbc66f68bc3baa8294c1fea46d8940f8a692db named entity 'CONTROLLED BY' named entity 'COMPLEX TRAIT' named entity 'HEPATOMEGALY' named entity 'GENETIC LOCI' named entity 'ASSOCIATED WITH' named entity 'PROCESS' named entity 'VARIATIONS' named entity 'DIRECTLY' named entity 'DISSECTING' named entity 'FEMALE' named entity 'LIVER WEIGHT' named entity 'NOVEL' named entity 'MAPPING' named entity 'USING' named entity 'BACKGROUND' named entity 'THESE' named entity 'DISEASES ETIOLOGY' named entity 'UNDERLYING' named entity 'POPULATIONS' named entity 'SEARCH' named entity 'INVOLVED' named entity 'CANDIDATE GENES' named entity 'KEY' named entity 'RELATED' named entity 'VARIATIONS' named entity 'IS A' named entity 'ROLE' named entity 'polygenic' named entity 'controlled' named entity 'genetic architecture' named entity 'Liver' named entity 'Collaborative' named entity 'variations' named entity 'Liver' named entity 'etiology' named entity 'key role' named entity 'liver' named entity 'medical knowledge' named entity 'phenotypic traits' named entity 'randomization tests' named entity 'adipose tissues' named entity 'Mouse Phenome Database' named entity 'postnatal' named entity 'body growth' named entity 'population model' named entity 'human diseases' named entity 'regulatory mechanisms' named entity 'metabolic' named entity 'inbred' named entity 'mice' named entity 'adipogenesis' named entity 'epigenetics' named entity 'null mice' named entity 'WSB' named entity 'rodent' named entity 'randomization' named entity 'QTL' named entity 'haplotype' named entity 'genetically diverse' named entity 'liver' named entity 'TAU' named entity 'genotype' named entity 'heritability' named entity 'animal models' named entity 'genetic background' named entity 'hepatoma' named entity 'liver' named entity '12 weeks'

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