About: Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6

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About: Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6
Creator	Santoni, Angela Gismondi, Angela Frati, Luigi Mainiero, Fabrizio Morrone, Stefania Palmieri, Gabriella Piccoli, Mario
source	PMC
abstract	Very late antigens VLA-1, VLA-2, VLA-3, and VLA-6, belonging to the beta 1 subfamily of integrins, have been identified as receptors for different binding domains of laminin (LM). We have detected VLA-6, but not VLA-1 and VLA-2 on a subset (50-70%) of fresh peripheral blood CD3- , CD16+, CD56+ human natural killer (NK) cells by immunofluorimetric and biochemical analysis. Binding assays performed on LM-coated plates showed that 10-15% of NK cells spontaneously adhere to LM, and this adhesion is mediated by VLA-6. Activation of NK cells through CD16 triggering or by phorbol ester results in a rapid increase of adhesion to LM, which is still mediated by VLA-6. The enhanced adhesiveness is not associated with changes in beta 1 LM receptor expression, while it correlates with changes in the phosphorylation status of alpha 6 subunit. The expression of VLA-6 on NK cells and the modulation of its avidity by activating stimuli may be relevant for NK cell migration and tissue location during inflammation or immune response.
has issue date	1992-11-01(xsd:dateTime)
bibo:pmid	1402670
has license	cc-by-nc-sa
sha1sum (hex)	e0d4c25b7e80c41abb0a816770a803b29746b2ee
resource representing a document's title	Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6
has PubMed Central identifier	PMC2119439
has PubMed identifier	1402670
schema:publication	J Exp Med
resource representing a document's body	covid:e0d4c25b7e80c41abb0a816770a803b29746b2ee#body_text
is schema:about of	named entity 'LAMININ' named entity 'LATE' named entity 'BELONGING' named entity 'ADHERE TO' named entity 'STATUS' named entity 'PERIPHERAL BLOOD' named entity 'PHOSPHORYLATION' named entity 'VLA' named entity 'LOCATION' named entity 'CELLS' named entity 'TRIGGERING' named entity 'ADHESION' named entity 'RECEPTORS' named entity 'BIOCHEMICAL ANALYSIS' named entity 'SUBSET' named entity 'PLATES' named entity 'CD16' named entity 'ITS' named entity 'CD16' named entity 'laminin' named entity 'triggering' named entity 'receptors' covid:arg/e0d4c25b7e80c41abb0a816770a803b29746b2ee named entity 'SPONTANEOUSLY' named entity 'NK CELL' named entity 'ASSOCIATED WITH' named entity 'RAPID' named entity 'RESULTS' named entity 'IDENTIFIED' named entity 'INFLAMMATION' named entity 'VLA-6' named entity 'INCREASE' named entity 'TRIGGERING' named entity 'ADHESION' named entity 'RECEPTOR EXPRESSION' named entity 'CELL MIGRATION' named entity 'LAMININ' named entity 'BINDING' named entity 'DETECTED' named entity 'AVIDITY' named entity 'INTEGRINS' named entity 'PERFORMED' named entity 'PHORBOL ESTERS' named entity 'ANTIGEN' named entity 'NK CELLS' named entity 'CD16' named entity 'TISSUE' named entity 'MEDIATED' named entity 'MAY BE' named entity 'SUBFAMILY' named entity 'ADHESIVENESS' named entity 'VLA-1' named entity 'BUT' named entity 'NATURAL KILLER' named entity 'RELEVANT' named entity 'STIMULI' named entity 'CD3' named entity 'CD56' named entity 'BINDING ASSAYS' named entity 'IMMUNE RESPONSE' named entity 'PHORBOL ESTER' named entity 'ANTIGENS' named entity 'EXPRESSION' named entity 'CHANGES' named entity 'LATE' named entity 'DIFFERENT' named entity 'COATED' named entity 'HAVE' named entity 'FRESH' named entity 'MODULATION' named entity '70%' named entity 'ACTIVATION' named entity 'ENHANCED' named entity 'NK CELLS' named entity 'ACTIVATING' named entity 'VLA-2' named entity 'HUMAN'

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