About: Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study

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About: Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study
Creator	Alfieri, Amauri Headley, Selwyn Pereira, Alfredo Garcia, João Hugo, Victor Marutani, B Michelazzo, Mariana Moreira, Jéssica Oliveira, Thalita Pires, Bárbara Santis, Giovana Xavier, Ana
Source	Medline; PMC
abstract	A retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals were reviewed to determine the pattern of histopathologic lesions. The intralesional identification of antigens of canine (distemper) morbillivirus (CDV), canine adenovirus-1 and -2 (CAdV-1 and -2), canine parvovirus-2 (CPV-2), Toxoplasma gondii, and Neospora caninum was evaluated by IHC within the histopathologic patterns observed. All puppies contained CDV nucleic acid by molecular testing. The most frequent histopathologic patterns were intestinal crypt necrosis (n = 8), white matter cerebellar demyelination (n = 7), necrohaemorrhagic hepatitis (n = 7), interstitial pneumonia (n = 7), and gallbladder oedema (n = 5). All puppies contained intralesional antigens of CDV in multiple tissues resulting in singular (n = 3), and concomitant dual (n = 3), triple (n = 5) and quadruple (n = 4) infections by CAdV-1, and -2, CPV-2, and N. caninum; T. gondii was not identified. Concomitant infections by CDV was observed with N. caninum (100%; 1/1), CPV-2 (100%; 8/8), CAdV-1 (100%; 8/8), and CAdV-2 (100%; 8/8). Intralesional antigens of CDV and not CAdV-1 were identified in cases of gallbladder oedema. The “blue eye” phenomenon was histologically characterized by corneal oedema and degenerative lesions to the corneal epithelium, without inflammatory reactions.
has issue date	2018-09-07(xsd:dateTime)
bibo:doi	10.1038/s41598-018-31540-0
bibo:pmid	30194440
has license	cc-by
sha1sum (hex)	e0bf08186f4d0b6112d6f4b8535584739da35596
schema:url	https://doi.org/10.1038/s41598-018-31540-0
resource representing a document's title	Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study
has PubMed Central identifier	PMC6128882
has PubMed identifier	30194440
schema:publication	Sci Rep
resource representing a document's body	covid:e0bf08186f4d0b6112d6f4b8535584739da35596#body_text
is schema:about of	named entity 'canine' named entity 'singular' named entity 'dual' named entity 'slides' named entity 'morbillivirus' named entity 'identification' named entity 'animals' covid:arg/e0bf08186f4d0b6112d6f4b8535584739da35596 named entity 'triple' named entity 'gallbladder' named entity 'pathogenesis' named entity 'patterns' named entity 'pathology' named entity 'puppies' named entity 'gallbladder' named entity 'autopsy' named entity 'Invitrogen' named entity 'epithelial cells' named entity 'hepatocytes' named entity 'histological' named entity 'antigens' named entity 'ballooning degeneration' named entity 'intravascular' named entity 'hydrogen peroxide' named entity 'immunosuppressed' named entity 'hepatitis' named entity 'uveitis' named entity 'nucleic acid' named entity 'CDV' named entity 'small intestine' named entity 'CDV' named entity 'RT-PCR' named entity 'demyelination' named entity 'protein' named entity 'N. caninum' named entity 'antigens' named entity 'autopsies' named entity 'haemorrhagic' named entity 'CDV' named entity 'interleukin-4' named entity 'canine' named entity 'oedematous' named entity 'corneal epithelium' named entity 'bronchus' named entity 'corneal epithelium' named entity 'autopsy' named entity 'demyelination' named entity 'pathogens' named entity '8/15' named entity 'gallbladder' named entity 'CDV' named entity 'cornea' named entity 'RT-PCR' named entity 'ethidium bromide' named entity 'neutrophils' named entity 'Thermo Fisher Scientific' named entity 'neurological dysfunction' named entity 'infectious disease' named entity 'oedema' named entity 'serosal' named entity 'ocular disease' named entity 'CDV' named entity 'breeds of dogs' named entity 'inoculation' named entity 'infection' named entity 'histopathologic' named entity 'gene' named entity 'oedema' named entity 'viral infections' named entity 'T. gondii'

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