About: Vaccination With a Single Consensus Envelope Protein Ectodomain Sequence Administered in a Heterologous Regimen Induces Tetravalent Immune Responses and Protection Against Dengue Viruses in Mice

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About: Vaccination With a Single Consensus Envelope Protein Ectodomain Sequence Administered in a Heterologous Regimen Induces Tetravalent Immune Responses and Protection Against Dengue Viruses in Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vaccination With a Single Consensus Envelope Protein Ectodomain Sequence Administered in a Heterologous Regimen Induces Tetravalent Immune Responses and Protection Against Dengue Viruses in Mice
Creator	Qiu, Chao Chen, Hui An, Jing Fan, Dongying Feng, Kaihao Gao, Na Sun, Jin Wang, Ran Zheng, Xiaoyan Forrester, Naomi An, Cn, Jing Khaiboullina, Svetlana Xia, Jin Xia, Jin Xjin@ips
Source	PMC
abstract	The development of a safe and effective tetravalent dengue vaccine that elicits protection against all dengue virus (DENV) serotypes is urgently needed. The consensus sequence of the ectodomain of envelope (E) protein of DENV (cE80) has been examined as an immunogen previously. In the current study, a cE80 DNA (D) vaccine was constructed and evaluated in conjunction with the cE80 protein (P) vaccine to examine whether both vaccines used together can further improve the immune responses. The cE80 DNA vaccine was administrated using either a homologous (DNA alone, DDD) or heterologous (DNA prime-protein boost: DDP or DPP) regimen, and evaluated for immunogenicity and protective efficacy in mice. Among the three DNA-based immunization regimens tested, DDP immunization is the optimal immunization regimen that elicited the greatest systemic immune response and conferred protection against all four DENV serotypes. This work provides innovative ideas for the development of consensus E-based dengue vaccines and the testing of optimal immunization regimens.
has issue date	2019-05-10(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.01113
bibo:pmid	31134046
has license	cc-by
sha1sum (hex)	e09ca57e55d73869520543f456019ee081d88a00
schema:url	https://doi.org/10.3389/fmicb.2019.01113
resource representing a document's title	Vaccination With a Single Consensus Envelope Protein Ectodomain Sequence Administered in a Heterologous Regimen Induces Tetravalent Immune Responses and Protection Against Dengue Viruses in Mice
has PubMed Central identifier	PMC6524413
has PubMed identifier	31134046
schema:publication	Front Microbiol
resource representing a document's body	covid:e09ca57e55d73869520543f456019ee081d88a00#body_text
is schema:about of	named entity 'DENGUE VIRUSES' named entity 'HETEROLOGOUS' named entity 'DENV' named entity 'envelope' named entity 'consensus sequence' named entity 'mice' named entity 'DNA' named entity 'DDP' named entity 'serotypes' named entity 'Viruses' named entity 'PROTEIN ' named entity 'PROTECTION' named entity 'ECTODOMAIN' named entity 'CONSENSUS' named entity 'SYSTEMIC' named entity 'PREVIOUSLY' named entity 'DNA VACCINE' named entity 'DDD' named entity 'VACCINE' named entity 'DENGUE VACCINES' named entity 'TESTED' named entity 'USING' named entity '28P' named entity 'PROVIDES' named entity 'IMMUNOGENICITY' named entity 'CONSENSUS SEQUENCE' named entity 'DNA' named entity 'SEROTYPES' named entity 'TESTING' named entity 'IMMUNE RESPONSE' named entity 'BOOST' named entity 'DPP' named entity 'EFFECTIVE' named entity 'IMMUNE RESPONSES' named entity 'CONJUNCTION' named entity 'ELICITS' named entity 'EFFICACY' named entity 'TO EXAMINE' named entity 'SAFE' named entity 'PROTECTION' named entity 'BASED' named entity 'IMMUNOGEN' named entity 'ADMINISTERED' named entity 'EVALUATED' named entity 'IMMUNE RESPONSES' named entity 'REGIMEN' named entity 'SEQUENCE' named entity 'CONSENSUS' named entity 'MICE' named entity 'ECTODOMAIN' named entity 'OPTIMAL' named entity 'STUDY' named entity 'PROTEIN ' named entity 'DEVELOPMENT' named entity 'DENGUE VIRUS' named entity 'IDEAS' named entity 'EXAMINED' named entity 'DDP' named entity 'CONSTRUCTED' named entity 'NEEDED' named entity 'HOMOLOGOUS' named entity 'GREATEST' named entity 'SINGLE' named entity 'ENVELOPE PROTEIN' named entity 'USED' named entity 'PRIME' named entity 'EITHER'

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