About: The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification

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About: The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
Creator	Wang, Na Wang, Haiyan Yang, Xiaoping Li, Yue Jiang, Wenqing Yang, Xinai
topic	covid:e08df4e841ead7ed6a287817e2a4ee80a05cc1fe#this
Source	PMC
abstract	Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. There is urgent need to understand the phylogeny, divergence and origin of SARS-CoV-2. Materials & methods: A recent study claimed that there was 17% divergence between SARS-CoV-2 and RaTG13 (a SARS-related coronaviruses) on synonymous sites by using sequence alignment. We re-analyzed the sequences of the two coronaviruses with the same methodology. Results: We found that 87% of the synonymous substitutions between the two coronaviruses could be potentially explained by the RNA modification system in hosts, with 65% contributed by deamination on cytidines (C-T mismatches) and 22% contributed by deamination on adenosines (A-G mismatches). Conclusion: Our results demonstrate that the divergence between SARS-CoV-2 and RaTG13 has been overestimated.
has issue date	2020-03-24(xsd:dateTime)
bibo:doi	10.2217/fvl-2020-0066
has license	cc-by
sha1sum (hex)	e08df4e841ead7ed6a287817e2a4ee80a05cc1fe
schema:url	https://doi.org/10.2217/fvl-2020-0066
resource representing a document's title	The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
has PubMed Central identifier	PMC7346715
resource representing a document's body	covid:e08df4e841ead7ed6a287817e2a4ee80a05cc1fe#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e08df4e841ead7ed6a287817e2a4ee80a05cc1fe
is schema:about of	named entity 'SARS-CoV-2' named entity 'sequences' named entity 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'methodology' named entity 'phylogeny' named entity 'hosts' named entity 'SARS-CoV-2' named entity 'RNA modification' named entity 'extensive' named entity 'SARS-CoV-2' named entity 'divergence' named entity 'coronaviruses' named entity 'RNA modification' named entity 'coronaviruses' named entity 'Aim' named entity 'deamination' named entity 'phylogeny' named entity 'RNA modification' named entity 'RNA modification' named entity 'SARS-CoV-2' named entity 'gene' named entity 'synonymous substitutions' named entity 'mutation rate' named entity 'mutation' named entity 'synonymous mutations' named entity 'mutation' named entity 'SARS-CoV-2' named entity 'nonredundant' named entity 'SARS-CoV-2' named entity 'missense' named entity 'sequence alignment' named entity 'ORFs' named entity 'mutation' named entity 'virologists' named entity 'silent mutations' named entity 'evolutionary biologists' named entity 'RNA modification' named entity 'RNA modification' named entity 'digestion' named entity 'codon' named entity 'orthologous' named entity 'experimental evidence' named entity 'SARS-CoV-2' named entity 'coronavirus' named entity 'ORF' named entity 'codons' named entity 'SARS-CoV-2' named entity 'host cells' named entity 'ORFs' named entity 'synonymous substitutions' named entity 'deamination' named entity 'RNA modification' named entity 'SARS-CoV-2' named entity 'virology' named entity 'SARS-CoV-2' named entity 'ORFs' named entity 'mutation' named entity 'Amino acids' named entity 'mutation' named entity 'synonymous substitution' named entity 'HCV' named entity 'SARS-CoV-2' named entity 'replication errors' named entity 'protease' named entity 'SARS-CoV-2' named entity 'missense' named entity 'synonymous substitutions' named entity 'inosine' named entity 'sequence alignment' named entity 'deamination' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'missense' named entity 'RNA viruses' named entity 'synonymous substitutions' named entity 'SARS-CoV-2' named entity 'codons'

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