About: The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection
Creator	Cagliani, Rachele Clerici, Mario Pontremoli, Chiara Sironi, Manuela Gori, Andrea Migliorino, Guglielmo Rossi, Marianna
Source	PMC
abstract	BACKGROUND: Host genetic factors are thought to modulated the severity of disease caused by infection with the 2009 H1N1 pandemic influenza virus (H1N1pdm09). The human CCR5 gene encodes a cytokine receptor important for cell-mediated immune response against H1N1pdm09. A 32-bp polymorphic deletion in the coding sequence of CCR5, the so-called CCR5Δ32 allele, segregates in populations of European ancestry with a frequency of 8-15%. A high proportion of CCR5Δ32 heterozygotes was reported in a sample of white Canadian critically-ill H1N1pdm09 infected subjects, suggesting an association with disease severity. METHODS: We recruited 29 H1N1pdm09 infected subjects from Southern Europe (mostly Italians) with a wide clinical spectrum of disease symptoms; the sample included 7 subjects who developed acute respiratory distress syndrome requiring extracorporeal membrane oxygenation. The CCR5Δ32 variant was genotyped in all subjects. RESULTS: The CCR5Δ32 allele was found in one single subject, who developed a very mild form and was not hospitalized. CONCLUSIONS: The CCR5Δ32 allele was not found to be associated with the risk of H1N1pdm09 infection or with a severe disease course.
has issue date	2014-08-07(xsd:dateTime)
bibo:doi	10.1186/1756-0500-7-504
bibo:pmid	25100510
has license	cc-by
sha1sum (hex)	e080709b3261852cfcfe8cdf4ff8192e06b4dcb5
schema:url	https://doi.org/10.1186/1756-0500-7-504
resource representing a document's title	The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection
has PubMed Central identifier	PMC4132245
has PubMed identifier	25100510
schema:publication	BMC Res Notes
resource representing a document's body	covid:e080709b3261852cfcfe8cdf4ff8192e06b4dcb5#body_text
is schema:about of	named entity 'subjects' named entity 'acute respiratory distress syndrome' named entity 'virus' named entity 'Methods' named entity 'GENETIC FACTORS' named entity 'FOUND' named entity 'SUBJECT' named entity 'SINGLE' named entity 'PANDEMIC' named entity 'FREQUENCY' named entity 'HOSPITALIZED' named entity 'subjects' named entity 'subjects' named entity 'CCR5' named entity 'infection' named entity 'European ancestry' named entity 'genotyped' named entity 'cytokine receptor' named entity 'H1N1 pandemic influenza virus' named entity 'heterozygotes' named entity 'genotyped' named entity 'cell-mediated immune response' named entity 'allele' named entity 'infection' named entity 'mild' named entity 'H1N1 outbreak' named entity 'Southern Europe' named entity 'ethical standards' named entity 'infection' named entity 'Asia' named entity 'critically ill patients' named entity 'life-threatening' named entity 'clinical characteristics' named entity 'ARDS' named entity 'diabetes' named entity 'Ccr5' named entity 'genetic variants' named entity 'symptomatic infection' named entity 'infection' named entity 'non-genetic' named entity 'case-control study' named entity 'false positives' named entity 'genetic effects' named entity 'heterozygous' named entity 'allele' named entity 'Europe' named entity 'ECMO' named entity 'genetic data' named entity 'viral species' named entity 'H1N1pdm09' named entity 'CCR5' named entity 'influenza virus' named entity 'respiratory complications' named entity 'allele' named entity 'PCR amplification' named entity 'genotyped' named entity 'mice' named entity 'Horby' named entity 'CCR5-D32' named entity 'immunosuppression' named entity 'recessive' named entity 'gene' named entity 'cell-mediated immune response' named entity 'H1N1 infection' named entity 'ARDS' named entity 'gene' named entity 'recessive' named entity 'Acute respiratory distress syndrome' named entity 'allele' named entity 'CCR5' named entity 'genetic factors' named entity 'cardiovascular disease' named entity 'genetic analyses' named entity 'pulmonary disease' named entity 'homozygous'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software