About: Application and optimization of RT-PCR in diagnosis of SARS-CoV-2 infection

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About: Application and optimization of RT-PCR in diagnosis of SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Application and optimization of RT-PCR in diagnosis of SARS-CoV-2 infection
Creator	Shan, Hong Liu, Wei Liu, Yan Chen, Chaoqun Jiang, Chen, Hongtao Guo, Zhaowang Jiang, Guanmin Ren, Xiaoshuai Shan, 4# Xiao, Qiang Zhang, Yaqin Zhou, Jianhui
Source	MedRxiv
abstract	Background: Coronavirus Disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global threat to public health. Aiming to construct an efficient screening pattern, we comprehensively evaluated the performances of RT-PCR and chest CT in diagnosing COVID-19. Methods: The records including demographics, RT-PCR, and CT from 87 confirmed COVID-19 cases and 481 exclusion cases were collected. The diagnostic accuracy of the pharyngeal swab RT-PCR, CT, combination with the second pharyngeal swab RT-PCR or with CT were evaluated individually. Besides, all the stool RT-PCR results were plotted by time to explore the value of stool RT-PCR. Findings: Combination of RT-PCR and CT has the higher sensitivity (91.9%,79/86) than RT-PCR alone (78.2%，68/87) or CT alone (66.7%, 54 of 81) or combination of two RT-PCR tests (86.2%,75/87). There was good agreement between RT-PCR and CT (kappa-value, 0.430). In 34 COVID-19 cases with inconsistent results, 94.1% (n=32) are mild infection, 62.5% of which (20/32) showed positive RT-PCR. 46.7% (35/75) COVID-19 patients had at least one positive stool during the course. Two cases had positive stool earlier than the pharyngeal swabs. Importantly, one patient had consecutive positive stool but negative pharyngeal swabs. Interpretation: Combination of RT-PCR and CT with the highest sensitivity is an optimal pattern to screen COVID-19. RT-PCR is superior to CT in diagnosing mild infections. Stool RT-PCR should be considered as an item for improving discovery rate and hospital discharge. This study shed light for optimizing scheme of screening and monitoring of SARS-CoV-2 infection.
has issue date	2020-02-27(xsd:dateTime)
bibo:doi	10.1101/2020.02.25.20027755
has license	medrxiv
sha1sum (hex)	e046a06f262d74d025272ad697d358c4afb5d9bd
schema:url	https://doi.org/10.1101/2020.02.25.20027755
resource representing a document's title	Application and optimization of RT-PCR in diagnosis of SARS-CoV-2 infection
resource representing a document's body	covid:e046a06f262d74d025272ad697d358c4afb5d9bd#body_text
is schema:about of	named entity 'RT-PCR' named entity 'APPLICATION' covid:arg/e046a06f262d74d025272ad697d358c4afb5d9bd named entity 'SCREENING' named entity 'SYNDROME' named entity 'EFFICIENT' named entity 'COVID-19' named entity 'OPTIMIZATION' named entity 'GLOBAL' named entity 'CONSTRUCT' named entity 'EVALUATED' named entity 'CORONAVIRUS' named entity 'PUBLIC HEALTH' named entity 'RT-PCR' named entity 'PATTERN' named entity 'THREAT' named entity 'DIAGNOSING' named entity 'PERFORMANCES' named entity 'DIAGNOSIS' named entity 'CHEST CT' named entity 'Application' named entity 'COVID' named entity 'chest CT' named entity 'preprint' named entity 'preprint' named entity 'real-time RT-PCR' named entity 'COVID' named entity 'preprint' named entity 'fever' named entity 'COVID' named entity 'CT scan' named entity 'Sun Yat-sen University' named entity 'preprint' named entity 'preprint' named entity 'MERS' named entity 'Hubei province' named entity 'statistical significance' named entity 'medRxiv' named entity 'China' named entity 'medRxiv' named entity 'preprint' named entity 'pneumonia' named entity 'severe acute respiratory syndrome' named entity 'pharyngeal' named entity 'CC-BY-ND' named entity 'SARS-CoV-2' named entity 'Wuhan' named entity 'Wuhan' named entity 'statistical analysis' named entity 'preprint' named entity 'CT scan' named entity 'preprint' named entity 'serial number' named entity 'preprint' named entity 'COVID' named entity 'respiratory symptoms' named entity 'CC-BY-ND' named entity 'pharyngeal' named entity 'RT-PCR' named entity 'preprint' named entity 'COVID-19' named entity 'Zhuhai' named entity 'medRxiv' named entity '2019-nCoV' named entity 'pneumonia' named entity 'CC-BY-ND' named entity 'cough' named entity 'CC-BY-ND' named entity 'medRxiv' named entity 'medRxiv' named entity 'pneumonia' named entity 'COVID-19' named entity 'epidemiology'

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